Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health
| Autor: | Andrea Ferreira Zandona, Gary D. Slade, Yu Gu, John S. Preisser, Patricia V. Basta, Di Wu, Poojan Shrestha, Beau D Meyer, Deepti Shroff Karhade, Jeannie Ginnis, Ashwini R Joshi, Kimon Divaris, Miguel Simancas-Pallares, Cary S. Agler, M. Andrea Azcarate-Peril, Apoena de Aguiar Ribeiro, Hunyong Cho, Kari E. North |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
community-based studies Health Toxicology and Mutagenesis Ethnic group lcsh:Medicine Genome-wide association study Oral Health Demographic profile Oral health Dental Caries Article 03 medical and health sciences 0302 clinical medicine children early childhood caries genomics North Carolina Prevalence Medicine Humans 030212 general & internal medicine Early childhood Genotyping business.industry lcsh:R Public Health Environmental and Occupational Health Community Participation 030206 dentistry medicine.disease stomatognathic diseases Epidemiologic Studies Cross-Sectional Studies Child Preschool Cohort Female business Early childhood caries Demography Genome-Wide Association Study |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 17, Iss 8056, p 8056 (2020) Volume 17 Issue 21 |
| ISSN: | 1660-4601 1661-7827 |
| Popis: | Early childhood caries (ECC) is an aggressive form of dental caries occurring in the first five years of life. Despite its prevalence and consequences, little progress has been made in its prevention and even less is known about individuals&rsquo susceptibility or genomic risk factors. The genome-wide association study (GWAS) of ECC (&ldquo ZOE 2.0&rdquo ) is a community-based, multi-ethnic, cross-sectional, genetic epidemiologic study seeking to address this knowledge gap. This paper describes the study&rsquo s design, the cohort&rsquo s demographic profile, data domains, and key oral health outcomes. Between 2016 and 2019, the study enrolled 8059 3&ndash 5-year-old children attending public preschools in North Carolina, United States. Participants resided in 86 of the state&rsquo s 100 counties and racial/ethnic minorities predominated&mdash for example, 48% (n = 3872) were African American, 22% white, and 20% (n = 1611) were Hispanic/Latino. Seventy-nine percent (n = 6404) of participants underwent clinical dental examinations yielding ECC outcome measures&mdash ECC (defined at the established caries lesion threshold) prevalence was 54% and the mean number of decayed, missing, filled surfaces due to caries was eight. Nearly all (98%) examined children provided sufficient DNA from saliva for genotyping. The cohort&rsquo s community-based nature and rich data offer excellent opportunities for addressing important clinical, epidemiologic, and biological questions in early childhood. |
| Databáze: | OpenAIRE |
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