The Determination Of Treatment Effect Of Chitosan Oligosaccharide In Lambs With Experimentally Cryptosporidiosis
| Autor: | Onur Başbuğ, Ugur Aydogdu, Alparslan Coşkun, Zahid Tevfik Agaoglu, Ahmet Duran Ataş |
|---|---|
| Přispěvatelé: | Veteriner Fakültesi |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
040301 veterinary sciences Lamb animal diseases Cryptosporidiosis macromolecular substances Article Chitosan oligosaccharide 0403 veterinary science Excretion Vena Jugularis Animal science Food Animals CHITOSAN OLIGOSACCHARIDE Weight loss Internal medicine parasitic diseases medicine Treatment effect Hematology biology business.industry 0402 animal and dairy science technology industry and agriculture Drug administration 04 agricultural and veterinary sciences biology.organism_classification equipment and supplies 040201 dairy & animal science carbohydrates (lipids) Treatment Cryptosporidium parvum Animal Science and Zoology medicine.symptom business |
| Zdroj: | Small Ruminant Research |
| Popis: | Aydoğdu, Uğur (Balikesir Author) In this study, it was aimed to investigate the efficacy of chitosan oligosaccharide administrations in different doses of experimental infected lambs with Cryptosporidium parvum. 32 male lambs were used in the study and the lambs were divided into 4 groups with 8 lambs in each group. Groups 1, 2 and 3, twice a day, were administered chitosan oligosaccharide at a dose of 100, 500, and 1000 mg/kg for 7 days, respectively, with milk replacer. In group 4, lambs with cryptosporidiosis were subjected to normal feeding as control without drug administration. Clinical examinations of lambs were made before treatment (day 0) and on days 1, 3, 5 and 7 after treatment and 5 ml of blood was collected from vena jugularis for blood analysis of all lambs. Weight changes of lambs were recorded at 0, 7, 14, and 21 days. Stool specimens were collected pre-treatment (day 0) and on days 1, 3, 5, 7, 14 and 21 post-treatment to determine oocyst excretion of lambs with cryptosporidiosis. Lambs with a mean oocyte counts > 10 after stool examination were included to the treatment. Changes in clinical hematology, blood gases and biochemical parameters were observed during the course of treatment, but these changes were limited. Weight loss was observed at 7th day according to 0th day the lambs with experimental cryptosporidiosis but gradually weight increase was observed at 14th and 21st days and these changes were similar in all groups. Oocyst excretion decreased in all groups during treatment. According to 0th day, there was a significant (p < 0.05) decrease in oocyte excretions in the third day in group 1 and 2, and in day 5 in the group 3 and 4. Significant changes (p < 0.05) were observed in oocyst excretions on the third and fifth days among the groups. As a result, in lambs with experimental cryptosporidiosis, chitosan oligosaccharide improved in clinical signs and stool character shorter than the positive control group and the administration of chitosan oligosaccharide at doses of 100, 500 and 1000 mg/kg for 7 days significantly reduced oocyst excretion but not enough to remove cryptosporidiosis completely. Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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