Recurrence of HCV Infection in a Sustained Responder After Chemotherapy for Non-Hodgkin’s Lymphoma: Successful Retreatment
| Autor: | Konstantinos Thomopoulos, Konstantinos Mimidis, A.C. Tsamandas, M. Pallasopoulou, E. Fragopanagou, Ch. Lampropoulou-Karatza, N.C. Giannakoulas |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Hepatitis C virus medicine.medical_treatment Interferon alpha-2 medicine.disease_cause Antiviral Agents Gastroenterology Polyethylene Glycols Recurrence Pegylated interferon Internal medicine Antineoplastic Combined Chemotherapy Protocols Ribavirin Genotype medicine Humans Chemotherapy business.industry Lymphoma Non-Hodgkin Interferon-alpha virus diseases Cancer General Medicine Middle Aged medicine.disease Hepatitis C Recombinant Proteins digestive system diseases Non-Hodgkin's lymphoma Lymphoma Immunology Viral disease business medicine.drug |
| Zdroj: | The American Journal of the Medical Sciences. 336:73-76 |
| ISSN: | 0002-9629 |
| DOI: | 10.1097/maj.0b013e318159d1a8 |
| Popis: | It is known that sustained virological response (SVR) in patients with chronic hepatitis C is associated with sustained elimination of hepatitis C virus (HCV) and that late relapse after SVR in HCV patients is doubtful. A 47-year-old man with chronic hepatitis C genotype 3, achieved SVR after combination treatment with pegylated interferon and ribavirine for 6 months. Sixteen months later non-Hodgkin's lymphoma was diagnosed. After successful completion of chemotherapy for non-Hodgkin's lymphoma, he presented with HCV infection recurrence of the same genotype. Retreatment with the same schedule resulted in normalization of aminotransferases and disappearance of HCVRNA from the serum. This case suggests that recurrence of HCV infection in a sustained responder may be probable after immunosuppressive therapy. Prevention is currently impossible but retreatment may be successful. |
| Databáze: | OpenAIRE |
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