Immune-checkpoint blockade of CTLA-4 (CD152) in antigen-specific human T-cell responses differs profoundly between neonates, children, and adults
| Autor: | Franziska Braun, Myra Spiliopoulou, Katrin Vogel, Karen Lampe, Christian Beyer, Hang Fu, Monika C. Brunner-Weinzierl, Barbara M. Bröker, Maximilian Pech, Holger Lingel, Mandy Pierau, Aditya Arra, Christoph Arens |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Staphylococcus aureus medicine.drug_class T-Lymphocytes T cell Immunology Ipilimumab chemical and pharmacologic phenomena cd40l ctla-4 Monoclonal antibody 03 medical and health sciences 0302 clinical medicine children Antigen specific adults Humans Immunology and Allergy Medicine CTLA-4 Antigen s. aureus Immune Checkpoint Inhibitors RC254-282 Original Research multifunctional t-cells CD40 biology business.industry Infant Newborn Infant Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC581-607 neonates Immune checkpoint Blockade 030104 developmental biology medicine.anatomical_structure Oncology CTLA-4 Child Preschool 030220 oncology & carcinogenesis biology.protein Immunotherapy Immunologic diseases. Allergy business Research Article medicine.drug |
| Zdroj: | OncoImmunology, Vol 10, Iss 1 (2021) Oncoimmunology article-version (VoR) Version of Record |
| Popis: | The monoclonal antibody against CTLA-4, Ipilimumab, is a first-in-class immune-checkpoint inhibitor approved for treatment of advanced melanoma in adults but not extensively studied in children. In light of the fact that the immune response early in life differs from that of adults, we have applied a human in vitro model stimulating CD4+ T-cells from neonates, children (1–5 years), and adults antigen-specifically with Staphylococcus aureus (S. aureus) for assessment of CTLA-4 blockade early in life. We show that T-cell proliferation as well as frequencies of antigen-specific T-cells (CD40L+CD4+) were enhanced in neonatal T-cells upon CTLA-4 blockade showing a larger variance within the group (F-test p |
| Databáze: | OpenAIRE |
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