Effect of metoclopramide on angiotensins, aldosterone, and atrial peptide during hypoxia
| Autor: | Jürg Nussberger, H. R. Brunner, Ph. Leuenberger, Jérôme Biollaz, S. Vonmoos, Bernard Waeber |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty Physiology Metoclopramide Blood Pressure Hypoxemia Renin-Angiotensin System chemistry.chemical_compound Atrial natriuretic peptide Heart Rate Reference Values Physiology (medical) Internal medicine Renin–angiotensin system medicine Humans Hypoxia Aldosterone biology Chemistry Angiotensin II Sodium Angiotensin-converting enzyme Hypoxia (medical) Oxygen Endocrinology Blood pressure biology.protein Potassium medicine.symptom Angiotensin I Atrial Natriuretic Factor |
| Zdroj: | Journal of applied physiology (Bethesda, Md. : 1985). 69(6) |
| ISSN: | 8750-7587 |
| Popis: | The coupling of aldosterone with renin is altered during acute hypoxemia. We measured the various components of the renin-angiotensin system and the plasma levels of immunoreactive atrial natriuretic factor (iANF) during room air and hypoxic gas-mixture breathing before and after administration of metoclopramide, a competitive antagonist of dopamine. Seven resting volunteers were studied 1 wk apart under room air and hypoxic conditions (inspired O2 fraction 0.12). During hypoxemia, the release of aldosterone induced by metoclopramide was significantly smaller. This change was associated with a slight increase in iANF and with a decrease in plasma angiotensin II levels, without any change in immunoreactive blood angiotensin I concentrations. Plasma electrolytes and blood acid-base status did not show relevant changes, nor did blood pressure and heart rate. We conclude that the decreased aldosterone concentrations seen under hypoxemia are related to decreased angiotensin II levels. Other influences, such as elevated ANF, may also mediate this effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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