Pyruvate dose response studies targeting the vital signs following hemorrhagic shock
| Autor: | Chalut Carissa, Mike Bodo, Pushpa Sharma, Rodriguez Vanessa, Makler Vyacheslav |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Resuscitation
Mean arterial pressure medicine.medical_specialty business.industry resuscitation Blood infusion Effective dose (pharmacology) Hypertonic saline Pulse pressure Surgery chemistry.chemical_compound hemorrhagic shock Blood pressure Sodium pyruvate chemistry kerdo index sodium pyruvate Anesthesia Heart rate Emergency Medicine Medicine Original Article business |
| Zdroj: | Journal of Emergencies, Trauma, and Shock |
| ISSN: | 0974-519X 0974-2700 |
| Popis: | Objectives: To determine the optimal effective dose of sodium pyruvate in maintaining the vital signs following hemorrhagic shock (HS) in rats. Materials and Methods: Anesthetized, male Sprague-Dawley rats underwent computer-controlled HS for 30 minute followed by fluid resuscitation with either hypertonic saline, or sodium pyruvate solutions of 0.5 M, 1.0 M, 2.0 M, and 4.0 M at a rate of 5ml/kg/h (60 minute) and subsequent blood infusion (60 minute). The results were compared with sham and non- resuscitated groups. The animals were continuously monitored for mean arterial pressure, systolic and diastolic pressure, heart rate, pulse pressure, temperature, shock index and Kerdo index (KI). Results: The Sham group remained stable throughout the experiment. Non-resuscitated HS animals did not survive for the entire experiment due to non-viable vital signs and poor shock and KI. All fluids were effective in normalizing the vital signs when shed blood was used adjunctively. Sodium pyruvate 2.0 M was most effective, and 4.0 M solution was least effective in improving the vital signs after HS. Conclusions: Future studies should be directed to use 2.0 M sodium pyruvate adjuvant for resuscitation on multiorgan failure and survival rate in HS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|