Caffeine improves contrast sensitivity of freely moving rats
| Autor: | Satoshi Shimegi, Akinori Y Sato, Keisuke Tsunoda, Ryo Kurata, Ryo Mizuyama |
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| Rok vydání: | 2019 |
| Předmět: |
Male
media_common.quotation_subject Experimental and Cognitive Psychology Motor Activity Pharmacology Contrast Sensitivity 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Caffeine Sensation Animals Contrast (vision) Rats Long-Evans 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Staircase method media_common Chemistry Two-alternative forced choice 05 social sciences Central nervous system stimulant Visual sensitivity Rats Central Nervous System Stimulants Sensitivity (electronics) 030217 neurology & neurosurgery |
| Zdroj: | Physiology & Behavior. 199:111-117 |
| ISSN: | 0031-9384 |
| Popis: | Caffeine (1, 3, 7-trimethylxanthine) is a well-known central nervous system stimulant that affects various brain functions such as attention, memory and sensation. However, it remains unclear whether and how caffeine modulates visual ability such as contrast sensitivity (CS) and the CS-spatial frequency (SF) relationship. To investigate these points, we tested the effects of caffeine on the perceptual CS of rats under three SF conditions. CS was measured using a two-alternative forced choice (2AFC) grating detection task combined with a staircase method. Intraperitoneal administration of caffeine 30 min prior to the task improved CS in an SF-dependent manner, in which the improving effect was observed at 0.1 cycles/degree (cpd) of the optimal SF for rats but not at 0.5 or 1 cpd. We concluded that caffeine, a representative ingredient contained in foods or drinks consumed daily, leads to an improvement of perceptual visual sensitivity. |
| Databáze: | OpenAIRE |
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