Lornoxicam characteristically modulates cerebral pain-processing in human volunteers: a functional magnetic resonance imaging study
| Autor: | W. Tiefenthaler, Christian Kolbitsch, R. Esterhammer, Matthias Hohlrieder, C. Schnürer, Anja Ischebeck, Christian Kremser, Patrizia Moser, Michael Schocke, Heinrich M. Schubert, Karl Egger, Ingo H. Lorenz |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Analgesic Pain Hippocampus Piroxicam Physical Stimulation Lornoxicam medicine Humans Single-Blind Method Operculum (brain) Anterior cingulate cortex Pain Measurement Brain Mapping medicine.diagnostic_test Postcentral gyrus business.industry Anti-Inflammatory Agents Non-Steroidal Parietal lobe Brain Magnetic resonance imaging Magnetic Resonance Imaging Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia business medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 100:827-833 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/aen082 |
| Popis: | Background. Lornoxicam like other non-steroidal anti-inflammatory drugs (NSAIDs) is widely used for postoperative pain therapy. Evaluation of the effect of lornoxicam on cerebral processing of surgical pain was thus the aim of the present functional magnetic resonance imaging (fMRI) study. Methods. An fMRI-compatible pain model that mimics surgical pain was used to induce pain rated 4‐5 on a visual analogue scale (VAS) at the anterior margin of the right tibia in volunteers (n¼22) after i.v. administration of saline (n¼11) or lornoxicam (0.1 mg kg 21 )( n¼11). Results. Lornoxicam, which significantly reduced pain sensation [VAS: mean (SD) 4.6 (0.7) vs 1.2 (1.5)], completely suppressed pain-induced activation in the SII/operculum, anterior cingulate cortex, insula, parietal (inferior), prefrontal (inferior, medial), temporal (inferior, medial/ superior) lobe, cerebellum, and contralateral (e.g. left-sided) postcentral gyrus (SI). Only the hippocampus and the contralateral superior parietal lobe (BA 7) were activated. Conclusions. As compared with saline, lornoxicam typically suppressed pain-induced brain activation in all regions except the hippocampus. Furthermore, de novo activation was found in the contralateral, superior parietal lobe (BA 7). Br J Anaesth 2008; 100: 827‐33 |
| Databáze: | OpenAIRE |
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