Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)
| Autor: | Xueying Wu, Jun Zhao, Ren Shucheng, Song Jin, Qi Xue, Wei Guo, Pan Wang, Fang Lv, Henghui Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Lung adenocarcinoma Clinical Biochemistry RM1-950 complex mixtures 03 medical and health sciences 0302 clinical medicine Antigen Single cell transcriptome parasitic diseases medicine Single‐cell RNA sequencing Stage (cooking) Lung cancer Letter to the Editor Lung business.industry Tumor associated antigens Biochemistry (medical) Cancer medicine.disease Tumor associated antigen digestive system diseases 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Molecular Medicine Adenocarcinoma Therapeutics. Pharmacology business |
| Zdroj: | Biomarker Research Biomarker Research, Vol 9, Iss 1, Pp 1-4 (2021) |
| ISSN: | 2050-7771 |
| Popis: | It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs. Supplementary Information The online version contains supplementary material available at 10.1186/s40364-021-00287-8. |
| Databáze: | OpenAIRE |
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