High Prevalence of Hearing Impairment in Primary Congenital Hypothyroidism
| Autor: | Ronen Spiegel, Zohara Sharroni, Dan Nachtigal, Gilad Havazelet, Shlomo Almashanu, Shoshana Rath, Ora Hess, Yoav Zehavi, Tal Almagor, Yardena Tenenbaum-Rakover, Ghadir Elias-Assad, Dani Bercovich |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty medicine.diagnostic_test business.industry Clinical Thyroidology / Research Article Endocrinology Diabetes and Metabolism Levothyroxine 030209 endocrinology & metabolism medicine.disease Congenital hypothyroidism Conductive hearing impairment 03 medical and health sciences 0302 clinical medicine Otorhinolaryngology 030220 oncology & carcinogenesis medicine Etiology Primary congenital hypothyroidism Audiometry business Evoked Response Audiometry medicine.drug |
| Zdroj: | Eur Thyroid J |
| ISSN: | 2235-0640 |
| Popis: | Background: An association between hearing impairment (HI) and congenital hypothyroidism (CH) has been reported previously. However, in general, studies were retrospective and had small sample sizes, and the results were variable and inconclusive. The aim of our study was to assess the prevalence of HI among patients with CH and to examine factors potentially predictive of HI including severity of CH, etiology of CH, and timing of treatment initiation. Methods: Audiometry was undertaken prospectively in 66 patients aged 3–21 years diagnosed with primary CH and 49 healthy matched controls. All patients with HI underwent examination by an otolaryngologist, and in patients with sensorineural loss, brainstem evoked response audiometry was performed. A next-generation sequencing (NGS) panel for genes involved in deafness was performed in patients with sensorineural HI to exclude additional genetic etiologies. Results: HI was found in 19 patients (28.7%). Among them, 5 (7.6%) had moderate to severe bilateral sensorineural impairment and 14 (21.2%) had mild conductive HI. Conductive HI was bilateral in 5 of these patients (36%). None of the controls had HI. No specific etiology was found in patients with HI, and no differences were identified in age at diagnosis, age at initiation of levothyroxine (LT4) therapy, gender, or ethnicity between patients with and without HI. A nonsignificant trend toward lower mean screening TT4 levels was found in patients with HI (compared to those without HI) (3.42 vs. 5.34 μg/dL, p = 0.095). No pathogenic variants in genes attributed to HI were identified by NGS in the 5 patients with sensorineural deafness, indicating that HI in these patients was likely attributable to CH rather than other genetic etiologies. Conclusions: Our findings indicate a high prevalence of HI among patients with CH, predominantly of the conductive type. HI was not associated with the etiology of CH or with delayed initiation of LT4 therapy. Audiometry is recommended for children diagnosed with CH and repeat monitoring may be warranted to identify acquired HI and to prevent long-term sequelae of undiagnosed deafness. |
| Databáze: | OpenAIRE |
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