Plasma total homocysteine and carotid intima-media thickness in type 1 diabetes: A prospective study
| Autor: | Suzanne R. Thorpe, Timothy J. Lyons, Maria F. Lopes-Virella, Arpita Basu, Julie A. Stoner, Alicia J. Jenkins, Richard L. Klein, W. Timothy Garvey |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Homocysteine Hyperhomocysteinemia Comorbidity Carotid Intima-Media Thickness Sensitivity and Specificity Article Young Adult chemistry.chemical_compound Predictive Value of Tests Interquartile range Diabetes mellitus Internal medicine medicine Humans Prospective Studies Prospective cohort study Type 1 diabetes biology business.industry Smoking C-reactive protein Age Factors medicine.disease Lipids Surgery C-Reactive Protein Cross-Sectional Studies Diabetes Mellitus Type 1 Blood pressure Intima-media thickness chemistry Hypertension Disease Progression cardiovascular system Cardiology biology.protein Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Atherosclerosis. 236:188-195 |
| ISSN: | 0021-9150 |
| Popis: | Plasma total homocysteine (tHcy) has been positively associated with carotid intima-media thickness (IMT) in non-diabetic populations and in a few cross-sectional studies of diabetic patients. We investigated cross-sectional and prospective associations of a single measure of tHcy with common and internal carotid IMT over a 6-year period in type 1 diabetes.tHcy levels were measured once, in plasma obtained in 1997-1999 from patients (n = 599) in the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the observational follow-up of the Diabetes Control and Complications Trial (DCCT). Common and internal carotid IMT were determined twice, in EDIC "Year 6" (1998-2000) and "Year 12" (2004-2006), using B-mode ultra-sonography.After adjustment, plasma tHcy [median (interquartile range): 6.2 (5.1, 7.5) μmol/L] was significantly correlated with age, diastolic blood pressure, renal dysfunction, and smoking (all p 0.05). In an unadjusted model only, increasing quartiles of tHcy correlated with common and internal carotid IMT, again at both EDIC time-points (p 0.01). However, multivariate logistic regression revealed no significant associations between increasing quartiles of tHcy and the 6-year change in common and internal carotid IMT (highest vs. lowest quintile) when adjusted for conventional risk factors.In a type 1 diabetes cohort from the EDIC study, plasma tHcy measured in samples drawn in 1997-1999 was associated with measures of common and internal carotid IMT measured both one and seven years later, but not with IMT progression between the two time-points. The data do not support routine measurement of tHcy in people with Type 1 diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect