Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

Autor:	Chih Yi Chen, Biyun Qian, Jeong Seon Ryu, Sung Ick Cha, Wen Chang Wang, Dianke Yu, Zhenhong Zhao, Xueying Zhao, Yu Fang Chiu, Jae Sook Sung, Chih-Liang Wang, Ying-Huang Tsai, Chao A. Hsiung, Jeff Yuenger, Bryan A. Bassig, Yeul Hong Kim, Joseph F. Fraumeni, Reury Perng Perng, Zhang Huan, Jin Hee Kim, Chien Chung Lin, Kyoung Mu Lee, Jiucun Wang, Chin-Fu Hsiao, Ming Shyan Huang, Hu Wei, Stephen J. Chanock, Wen Tan, Liming Huang, Kyong Hwa Park, Zhihua Yin, Xiaoling Zhu, Nathaniel Rothman, Hongyan Chen, Joohyun Kim, Chen Wu, Jen Yu Hung, Fang Yu Tsai, Yangwu Ren, Qing Lan, Qiuyin Cai, Kexin Chen, Tsung-Ying Yang, Margaret A. Tucker, Sook Whan Sung, Chong-Jen Yu, Adeline Seow, Xuelian Li, Wong Ho Chow, Jun Suk Kim, Kuan-Yu Chen, Ju Yeon Park, Chien-Jen Chen, Wu Chou Su, Yong-Bing Xiang, Wei Zheng, Li Jin, Wei Wu, Ying Hsiang Chen, Amy Hutchinson, Kun-Chieh Chen, Neil E. Caporaso, Xiao-Ou Shu, Yen Li Lo, Yu Tang Gao, Tae Hoon Jung, In San Kim, H. Dean Hosgood, Meredith Yeager, Daru Lu, Yuh Min Chen, Gee-Chen Chang, Jae Yong Park, Dongxin Lin, Yun-Chul Hong, Chang Ho Kim, Nilanjan Chatterjee, Baosen Zhou, Yao Jen Li, I. Shou Chang, Young Tae Kim, Pan-Chyr Yang, Maria Teresa Landi, Ying Chen
Rok vydání:	2012
Předmět:	Risk Oncology medicine.medical_specialty Asia Lung Neoplasms Genotype Adenocarcinoma of Lung Genome-wide association study Single-nucleotide polymorphism Adenocarcinoma Biology Polymorphism Single Nucleotide Article Internal medicine Genetic variation Genetics medicine Humans Genetic Predisposition to Disease Allele Lung cancer Genetics (clinical) Squamous-cell carcinoma of the lung Tumor Suppressor Proteins Smoking Case-control study Genetic Variation medicine.disease Case-Control Studies Immunology Carcinoma Squamous Cell Female Genome-Wide Association Study Transcription Factors
Zdroj:	Human Genetics. 131:1197-1203
ISSN:	1432-1203 0340-6717
DOI:	10.1007/s00439-012-1144-8
Popis:	A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10(-12)); however, this association did not achieve genome-wide significance (p ≤ 10(-7)) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10(-8); allelic risk = 0.80, 95% confidence interval (CI) = 0.74-0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7731f8c473d92275c3eaa0d8bae0f3f1 https://doi.org/10.1007/s00439-012-1144-8 Zobrazit plný text záznamu Full text from SpringerLink