Predictors for High Microsatellite Instability in Patients with Colorectal Cancer Fulfilling the Revised Bethesda Guidelines
| Autor: | Hiroaki Nozawa, Takeshi Nishikawa, Koji Murono, Kazuhito Sasaki, Kazushige Kawai, Toshiaki Tanaka, Keiichi Arakawa, Masaya Hiyoshi, Shigenobu Emoto, Manabu Kaneko, Keisuke Hata, Yasutaka Shuno |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Colorectal cancer Guidelines as Topic 03 medical and health sciences 0302 clinical medicine Japan Internal medicine medicine Humans In patient Genetic Testing neoplasms Aged Retrospective Studies Aged 80 and over business.industry nutritional and metabolic diseases Microsatellite instability Retrospective cohort study General Medicine Odds ratio Middle Aged medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis digestive system diseases Lynch syndrome 030104 developmental biology Oncology 030220 oncology & carcinogenesis Female Microsatellite Instability business Microsatellite Repeats |
| Zdroj: | Anticancer Research. 38:4871-4876 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.12800 |
| Popis: | BACKGROUND The revised Bethesda guidelines (rBG) are generally used for screening of Lynch syndrome, and few researchers have investigated the associations between microsatellite instability (MSI) status and each item of the rBG. PATIENTS AND METHODS This retrospective study included patients with colorectal cancer who were classified into those fulfilling the rBG (Bethesda group) and those not (control group). The breakdown of each item in the rBG and predictors of high MSI (MSI-H) were determined in the Bethesda group. RESULTS Of 809 consecutive patients, 161 (19.9%) were found to fulfil the rBG criteria. As a predictor of MSI-H, items 2 or 5 of the rBG showed a sensitivity of 93.3%. Item 5 and right-sided tumour location were independent predictors of MSI-H in patients fulfilling the rBG (odds ratio(OR)=4.49 and 25.1; p=0.0260 and |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|