Effects of the (+) and (−) Enantiomers of the Antidepressant Drug Tianeptine on 5-HTP-induced Behaviour
| Autor: | Gerald Curzon, Ademola O. Oluyomi, Krishna P. Datla |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Pharmacology Behavior Animal Thiazepines Chemistry Stereoisomerism Antidepressive Agents Tricyclic Rats 5-Hydroxytryptophan Rats Sprague-Dawley Cellular and Molecular Neuroscience Mechanism of action Carbidopa medicine Animals Antidepressant Tianeptine Serotonin medicine.symptom Enantiomer Reuptake inhibitor 5-HT receptor medicine.drug |
| Zdroj: | Neuropharmacology. 36:383-387 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/s0028-3908(97)00016-6 |
| Popis: | The effects of the (+) and (-) enantiomers of the antidepressant drug tianeptine (5, 10, 20 mg/kg, i.p.) on wet dog shakes (WDS) and faecal pellet production induced by concurrently administered 5-hydroxytryptophan (5-HTP, 100 mg/kg, i.p.) given 30 min after carbidopa (25 mg/kg, i.p.) were investigated in rats. WDS scores peaked approximately 1 hr after giving 5-HTP and gradually declined over the next 2 hr. (-)-Tianeptine dose-dependently and significantly inhibited WDS. Inhibition became less marked with time after administration, but remained significant over the 3 hr period after the 10 and 20 mg/kg doses and during the first 40 min after the 5 mg/kg dose. (+)-Tianeptine caused slight inhibition without dose-dependence and slightly increased net inhibition when added to the (-) isomer (10 mg/kg). The induction of faecal pellet production by 5-HTP was significantly and dose-dependently inhibited by (-)-tianeptine. The (+) isomer neither altered this effect of 5-HTP nor its inhibition by (-)-tianeptine. Results show that inhibition of 5-HTP-induced WDS and faecal pellet formation by tianeptine was almost completely dependent on the (-) isomer. |
| Databáze: | OpenAIRE |
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