Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone
| Autor: | Dominik W. Schelshorn, Anne Järve, Jens O. Brömme, Carola Krüger, Wolfgang Kuschinsky, Heinrich F. Bürgers, Armin Schneider, Martin H. Maurer, Robert E. Feldmann, Fatemeh Sabouri |
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| Rok vydání: | 2007 |
| Předmět: |
Proteomics
Cellular differentiation Subventricular zone Apoptosis Biology Biochemistry Cerebral Ventricles Glycogen Synthase Kinase 3 GSK-3 medicine Animals Electrophoresis Gel Two-Dimensional GSK3B beta Catenin Cell Proliferation Neurons Glycogen Synthase Kinase 3 beta Cell growth Stem Cells Wnt signaling pathway Cell Differentiation General Chemistry Neural stem cell Cell biology Rats Wnt Proteins medicine.anatomical_structure Signal transduction |
| Zdroj: | Journal of proteome research. 6(3) |
| ISSN: | 1535-3893 |
| Popis: | On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3beta (GSK3beta) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/beta-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of beta-catenin target genes during GSK3beta inhibition, associated with decreased apoptosis. |
| Databáze: | OpenAIRE |
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