Mechanism of Glomerular Hyperfiltration After a Protein Meal in Humans: Role of hormones and amino acids
| Autor: | McKenna Ba, Lockwood Dh, Truglia Ja, Pabico Rc, Nair Ks, Statt M |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Renal function Kidney Glucagon Eating Reference Values Internal medicine Internal Medicine medicine Humans Insulin Infusions Intravenous Advanced and Specialized Nursing Alanine business.industry medicine.anatomical_structure Somatostatin Endocrinology Regional Blood Flow Growth Hormone Renal blood flow Dietary Proteins business Glomerular hyperfiltration Glomerular Filtration Rate Hormone |
| Zdroj: | Diabetes Care. 17:711-715 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.17.7.711 |
| Popis: | OBJECTIVES Previous studies demonstrated that protein meals and amino acid (AA) infusions increase glomerular nitration rate (GFR) and renal plasma flow (RPF) and that somatostatin (SRIH) infusion inhibits these increments. We tested whether a single AA such as alanine could increase GFR and RPF and whether the changes in GFR and RPF could be explained on the basis of changes in glucagon, growth hormone (GH), and insulin. RESEARCH DESIGN AND METHODS In the first experiment, alanine was infused with or without SRIH in five normal subjects. In the second experiment, five other subjects were infused with SRIH on three separate occasions. In a control study, insulin, glucagon, and GH were given at replacement doses; in a hyperglucagonemia study, glucagon was given at a rate of 0.2 μ · kg−1 · h−1 (hypoglucagonemia); and in a high GH study, GH was given at a rate of 2 /μg · kg−1· h−1. GFR and RPF were measured using inulin and para-aminohippurate, respectively. RESULTS Alanine increased GFR and RPF, whereas SRIH inhibited these changes (P < 0.05). Hyperglucagonemia or high GH with or without insulin failed to increase RPF or GFR. CONCLUSIONS A single AA such as alanine increases GFR and RPF, and this increase is dependent on a factor inhibited by SRIH. Although GH, glucagon, and insulin are factors inhibited by SRIH, none of these factors explains the changes in RPF and GFR in our acute studies. |
| Databáze: | OpenAIRE |
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