Renal discrimination between strontium and calcium in rats. Effects of renal damage caused by cadmium-metallothionein
| Autor: | Kazuo T. Suzuki, Naoko Sugihira |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Glycosuria
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Intraperitoneal injection Renal function chemistry.chemical_element Calcium In Vitro Techniques Kidney Biochemistry Inorganic Chemistry chemistry.chemical_compound Lactate dehydrogenase Internal medicine medicine Metallothionein Animals L-Lactate Dehydrogenase Biochemistry (medical) Rats Inbred Strains General Medicine Alkaline Phosphatase Rats Proteinuria Endocrinology medicine.anatomical_structure chemistry Strontium Alkaline phosphatase Female Kidney Diseases medicine.symptom |
| Zdroj: | Biological trace element research. 22(1) |
| ISSN: | 0163-4984 |
| Popis: | Renal functions were damaged at the reabsorptive site by the injection of cadmium-metallothionein (Cd-MT) and its effect on discrimination of chemically similar elements was examined for the two alkaline-earth elements, calcium (Ca) and strontium (Sr). Tubular damage was induced in female Wistar rats, 7 wk old, body wt 145.1 +/- 3.5 g (mean +/- S.D.), by an intraperitoneal injection of Cd-MT (400 micrograms Cd/kg body wt). The Cd-MT injection caused increases in urinary enzymes (lactate dehydrogenase; alkaline phosphatase), glucose, and total protein. Urinary Ca and Sr increased and urinary Sr/Ca ratio decreased rapidly after the Cd-MT injection. Both changes remained at significant levels throughout the experiment. On the other hand, renal Ca and Sr levels increased with time after 18 or 24 h and changed similarly. Although plasma levels of Ca and Sr slightly increased after 30 or 36 h post-injections, the plasma Sr/Ca level remained constant. A close exponential relationship formed between the relative clearances of Ca and Sr. There was no significant difference between the exponent of the following equation (K) for the Cd-MT-injected group and that for the control group. Sr clearance/creatinine clearance = (Ca clearance/creatinine clearance)K where K = 0.408 from experimental data for the two groups. This suggests that the discrimination mechanism between Sr and Ca during the reabsorptive step in the kidney is strictly regulated. |
| Databáze: | OpenAIRE |
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