Elemental compositions and anti-anemic property of Harungana madagascariensis stem bark
| Autor: | Clement O. Adewunmi, O. M. Daniyan, Isaac O. Oluborode, Ezekiel Olugbenga Iwalewa, Oluwatobi A. Fatokun, N. O. Omisore, Bamigboye J. Taiwo |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
High concentration Stem bark biology lcsh:RM1-950 X-ray fluorescence chemistry.chemical_element Heavy metals Zinc Manganese biology.organism_classification chemistry.chemical_compound lcsh:Therapeutics. Pharmacology chemistry visual_art Botany visual_art.visual_art_medium Harungana Anti-anemic activity Bark Harungana madagascariensis Phenylhydrazine Nuclear chemistry |
| Zdroj: | Bangladesh Journal of Pharmacology, Vol 4, Iss 2, Pp 115-121 (2009) Bangladesh Journal of Pharmacology, Vol 4, Iss 2 (2009) |
| ISSN: | 1991-0088 |
| Popis: | The concentrations of 15 elements and heavy metals in the stem bark of Harungana madagascariensis were determined using an energy-dispersive X-ray fluorescence (EDXRF) spectrometer . The anti-anemic activity was done using the changes in hematological parameters (PCV, RBC and Hb) influenced by phenylhydrazine HCL (80 mg/kg) and malaria parasites-induced anemia. Results shows Cd, Ni, Mo, Cr and Br were in the range of 0.021–0.94 mg/g, while Pb, Zn, Fe, Cu and Hg were in the range of 1.50–7.24 mg/g. The elements with very high concentration were Ca, K, Sr, Mn, and Cl and were in the range of 10.5–774.3 mg/g. Remarkable anti-anemic activity was obtained with PCV of 40–48%, RBC count of 81 -155 x10 4 and Hb value of 57-66 g/dL after treatment compared with 30% PCV, 67 x10 4 RBC count and 36.5 g/dL Hb value obtained for the untreated control animals. Our results suggest that H. madascariensis stem bark extract constituents’ exhibit anti-anemic activity. |
| Databáze: | OpenAIRE |
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