Microstructural white matter changes in carriers of the DYT1 gene mutation
| Autor: | Sherwin Su, Maren Carbon, Phoebe G. Spetsieris, Susan B. Bressman, David Eidelberg, Gwenn S. Smith, Peter B. Kingsley |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Diffusion tensor magnetic resonance imaging Biology White matter Fractional anisotropy medicine Humans Genetic Predisposition to Disease Cerebral Cortex Dystonia Supplementary motor area Middle Aged medicine.disease Dyt1 gene White matter changes Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Neurology Case-Control Studies Mutation Mutation (genetic algorithm) Female Neurology (clinical) Neuroscience Molecular Chaperones |
| Zdroj: | Annals of Neurology. 56:283-286 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.20177 |
| Popis: | We tested the hypothesis that the DYT1 genotype is associated with a disorder of anatomical connectivity involving primarily the sensorimotor cortex. We used diffusion tensor magnetic resonance imaging (DTI) to assess the microstructure of white matter pathways in mutation carriers and control subjects. Fractional anisotropy (FA), a measure of axonal integrity and coherence, was reduced (p < 0.005) in the subgyral white matter of the sensorimotor cortex of DYT1 carriers. Abnormal anatomical connectivity of the supplementary motor area may contribute to the susceptibility of DYT1 carriers to develop clinical manifestations of dystonia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text