Randomized Prospective Study of the Use of Anti-Inflammatory Drops After Selective Laser Trabeculoplasty
| Autor: | Maya De Belder, Myrjam De Keyser, Veva De Groot |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Intraocular pressure genetic structures medicine.drug_class Administration Topical Indomethacin Gonioscopy Glaucoma Trabeculectomy Lasers Solid-State Dexamethasone Anti-inflammatory law.invention Tonometry Ocular 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Humans Prospective Studies Prospective cohort study Glucocorticoids Intraocular Pressure Aged Inflammation Postoperative Care medicine.diagnostic_test business.industry Anti-Inflammatory Agents Non-Steroidal Middle Aged medicine.disease Uveitis Anterior eye diseases Ophthalmology Anesthesia 030221 ophthalmology & optometry Female Human medicine Laser Therapy sense organs Ophthalmic Solutions business Glaucoma Open-Angle 030217 neurology & neurosurgery Uveitis medicine.drug |
| Zdroj: | Journal of glaucoma |
| ISSN: | 1057-0829 1536-481X |
| Popis: | Purpose: Evaluating the use of Indomethacin, Dexamethasone, and no anti-inflammatory treatment immediately after selective laser trabeculoplasty (SLT). Materials and Methods: Prospective randomized clinical trial of 132 eyes. Both eyes of the patient underwent SLT. One of the eyes was treated with Indomethacin 0.1% or Dexamethasone 0.1% 3 times daily for 1 week; the other eye did not receive any anti-inflammatory treatment. Intraocular pressure (IOP) and inflammatory parameters were recorded at 1 hour, 1 week, 1, 3, and 6 months. Results: Cells in the anterior chamber were present in 57% to 71% of the patients after 1 hour. About 16% to 37% of the patients reported pain/discomfort after 1 hour. Redness was present before SLT in 29% to 34% of the patients, probably due to antiglaucoma medication. After 1 hour, the amount of redness recorded raised to 32% to 42%, but the amount of patients with redness returned to pretreatment levels after 1 week. An IOP peak of >5 mm Hg above baseline IOP 1 hour after laser was present in 3% to 9% of the patients. IOP lowered 11% to 21% compared with IOP at baseline. The number of medications needed changed from 1.45 to 1.49 before, to 0.23 to 0.45 six months after SLT. No differential effects based on the kind of anti-inflammatory treatment or no treatment were found for any of the parameters. Conclusions: SLT induces little inflammation: anti-inflammatory drops do not make a significant difference in pain, redness, cells in anterior chamber, or peak IOP following SLT. The IOP-lowering effect of the SLT is not influenced by the use of Indomethacin or Dexamethasone. |
| Databáze: | OpenAIRE |
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