Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα – IL-23 – IL-17 Axis
| Autor: | Päivi M Hägg, Minna E. Kubin, Nina Kokkonen, Riitta Palatsi, Kirsi-Maria Haapasaari, Tiina Hurskainen, Juha P. Väyrynen, Virpi Glumoff, Kaisa Tasanen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
CD4-Positive T-Lymphocytes
030213 general clinical medicine medicine.medical_specialty Time Factors Combination therapy Calcitriol Anti-Inflammatory Agents Dermatology CD8-Positive T-Lymphocytes Pharmacology Administration Cutaneous Betamethasone Interleukin-23 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Receptors Glucocorticoid 0302 clinical medicine Psoriasis Humans Medicine Glucocorticoids Calcipotriol Finland Skin Tumor Necrosis Factor-alpha business.industry Interleukin-17 Interleukin General Medicine medicine.disease Drug Combinations Treatment Outcome chemistry Tumor necrosis factor alpha Interleukin 17 Inflammation Mediators business Immunosuppressive Agents Signal Transduction medicine.drug |
| Zdroj: | Acta Dermato Venereologica. 97:449-455 |
| ISSN: | 0001-5555 |
| DOI: | 10.2340/00015555-2579 |
| Popis: | The effects of topical calcipotriol/betamethasone combination therapy and betamethasone monotherapy on inflammatory T-cell numbers and molecular markers were compared in patients with psoriasis. Combination therapy down-regulated the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-23A, IL-17A, S100A7, CCL-20 and interferon (IFN)-γ in skin and TNF-α, IL-6, IL-23A, T-bet and IFN-γ in peripheral blood mononuclear cells (PBMCs). Betamethasone monotherapy had less effect. Expression of FoxP3 in both skin and PBMCs was down-regulated by calcipotriol/betamethasone, but not by betamethasone. Immunohistochemical analysis revealed that calcipotriol/betamethasone reduced the numbers of CD4+ and CD8+ T cells and Tregs in psoriatic lesions more than betamethasone. Flow cytometric analyses demonstrated that calcipotriol/betamethasone decreased the numbers of circulating CD8+ T cells, Tregs, skin-homing Th17 memory cells and Th22 memory cells, while betamethasone had little or no effect. Glucocorticoid receptors GRα and GRß were expressed in psoriatic skin. In conclusion, calcipotriol increases the immunosuppressive power of betamethasone by suppressing the inflammatory TNF-α - IL-23 - IL-17 axis. |
| Databáze: | OpenAIRE |
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