Medical history of chemotherapy or immunosuppressive drug treatment and risk of amyotrophic lateral sclerosis (ALS)
| Autor: | Dominic N. Facciponte, Elijah W. Stommel, Angeline S. Andrew, Rup Tandan, Tracie A. Caller, Walter G. Bradley, Vinay Chaudhry, Patricia L. Henegan, Lora Clawson, Kristen M Riley, Thomas Kuczmarski |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Neuromuscular disease Neurology medicine.medical_treatment Population Antineoplastic Agents Disease Lower risk 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal medicine Odds Ratio medicine Humans Medical history Amyotrophic lateral sclerosis education Chemotherapy education.field_of_study business.industry Amyotrophic Lateral Sclerosis Smoking Age Factors Middle Aged medicine.disease United States Surgery Case-Control Studies 030220 oncology & carcinogenesis Female Neurology (clinical) business Immunosuppressive Agents 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology. 264:1763-1767 |
| ISSN: | 1432-1459 0340-5354 |
| Popis: | A recent population-based analysis demonstrated lower risk of the lethal degenerative neuromuscular disease, amyotrophic lateral sclerosis (ALS) associated with history of the use of 'antineoplastic agents' and 'immunosuppressants'. To see if this finding was generalizable to other ALS cohorts, we examined associations between use of these agents and ALS risk in an independent case-control study of n = 414 ALS patients and n = 361 controls in an Eastern US population. Controls were sampled from the general population and among non-neurodegenerative disease patients. A history of chemotherapy treatment was significantly associated with a decreased ALS risk (OR 0.46, 95% CI 0.22-0.89, P = 0.026). We did not observe an association between risk of ALS and immunosuppressant therapy use (OR 0.78, 95% CI 0.50-1.02, P = 0.23). Analyses were adjusted for age, gender, and smoking. Our results support the prior report for chemotherapy treatment and lead to further discussion of the underlying mechanism. |
| Databáze: | OpenAIRE |
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