Hepatitis E and Allogeneic Hematopoietic Stem Cell Transplantation: A French Nationwide SFGM-TC Retrospective Study

Autor: Régis Peffault de Latour, Reza Tabrizi, Johanna Konopacki, Vincent Mallet, Anne-Marie Roque-Afonso, Severine Lissandre, Aliénor Xhaard, Pierre-Simon Rohrlich, Stephanie Nguyen-Quoc, Florence Abravanel, Anne Huynh, Patricia Ribaud
Přispěvatelé: Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Physiopathologie et traitement des maladies du foie, Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépatologie médicale [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Physiopathologie du système immunitaire (Inserm U1223), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], Service d'Hématologie clinique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Bordeaux [Bordeaux], Hôpital d'instruction des Armées Percy, Service de Santé des Armées, Service d'hématologie [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau, CHU Toulouse [Toulouse], Gestionnaire, Hal Sorbonne Université, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Rok vydání: 2019
Předmět:
Male
[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology
Cirrhosis
allogeneic hematopoietic stem transplantation
[SDV]Life Sciences [q-bio]
viruses
medicine.medical_treatment
lcsh:QR1-502
MESH: Hematopoietic Stem Cell Transplantation* / adverse effects
Hematopoietic stem cell transplantation
medicine.disease_cause
lcsh:Microbiology
chemistry.chemical_compound
0302 clinical medicine
Hepatitis E virus
030212 general & internal medicine
MESH: Treatment Outcome
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
MESH: Aged
MESH: France / epidemiology
MESH: Middle Aged
medicine.diagnostic_test
Hematopoietic Stem Cell Transplantation
MESH: Ribavirin / therapeutic use
virus diseases
[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology
Middle Aged
Hepatitis E
3. Good health
[SDV] Life Sciences [q-bio]
Treatment Outcome
Infectious Diseases
Liver
MESH: Young Adult
MESH: Hepatitis E / immunology
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
MESH: Hepatitis E / therapy
MESH: Liver / physiopathology
Female
030211 gastroenterology & hepatology
France
Immunosuppressive Agents
Adult
medicine.medical_specialty
Context (language use)
Article
MESH: Hepatitis E / diagnosis
MESH: Liver / pathology
Young Adult
03 medical and health sciences
Virology
Internal medicine
Ribavirin
medicine
Humans
MESH: Hepatitis E virus / immunology
Aged
Retrospective Studies
MESH: Hepatitis E / epidemiology
MESH: Humans
business.industry
MESH: Hepatitis E virus / isolation & purification
MESH: Adult
MESH: Retrospective Studies
medicine.disease
MESH: Male
digestive system diseases
Transplantation
chemistry
MESH: Immunosuppressive Agents / adverse effects
hepatitis E
Liver function tests
business
MESH: Female
Zdroj: Viruses
Viruses, MDPI, 2019, 11 (7), pp.622. ⟨10.3390/v11070622⟩
Viruses, 2019, 11 (7), pp.622. ⟨10.3390/v11070622⟩
Volume 11
Issue 7
Viruses, Vol 11, Iss 7, p 622 (2019)
ISSN: 1999-4915
DOI: 10.3390/v11070622
Popis: Usually self-limited, hepatitis E virus (HEV) infection may evolve to chronicity and cirrhosis in immunosuppressed patients. HEV infection has been described in solid-organ transplantation and hematology patients, but for allogeneic hematopoietic stem cell transplant (alloHSCT) recipients, only small cohorts are available. This retrospective nationwide multi-center series aimed to describe HEV diagnostic practices in alloHSCT French centers, and the course of infection in the context of alloHSCT. Twenty-nine out of 37 centers participated. HEV search in case of liver function tests (LFT) abnormalities was never performed in 24% of centers, occasionally in 55%, and systematically in 21%. Twenty-five cases of active HEV infection were diagnosed in seven centers, all because of LFT abnormalities, by blood nucleic acid testing. HEV infection was diagnosed in three patients before alloHSCT
HEV infection did not influence transplantation planning, and resolved spontaneously before or after alloHSCT. Twenty-two patients were diagnosed a median of 283 days after alloHSCT. Nine patients (41%) had spontaneous viral clearance, mostly after immunosuppressive treatment decrease. Thirteen patients (59%) received ribavirin, with sustained viral clearance in 11/12 evaluable patients. We observed three HEV recurrences but no HEV-related death or liver failure, nor evolution to cirrhosis.
Databáze: OpenAIRE
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