Involvement of μ-opioid receptors and α-adrenoceptors in the immunomodulatory effects of dihydroetorphine
| Autor: | Feng-Yuan Li, Hui-Qing Bai, Ji-Wang Zheng, Ke-Ren Zhang, Wei-Ran Wu, Ying Li |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Dihydroetorphine medicine.drug_class Narcotic Antagonists Adrenergic beta-Antagonists Receptors Opioid mu Lymphocyte proliferation (+)-Naloxone Pharmacology Biology Mice Phentolamine Adjuvants Immunologic Internal medicine medicine Animals Lymphocytes Receptor Adrenergic alpha-Antagonists Mice Inbred BALB C Naloxone Antagonist Etorphine Receptors Adrenergic alpha Receptor antagonist Propranolol Analgesics Opioid Endocrinology Opioid Interleukin-2 Female Cell Division Immunosuppressive Agents medicine.drug |
| Zdroj: | European Journal of Pharmacology. 353:79-85 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(98)00369-0 |
| Popis: | The present study investigated the effects of acutely administered dihydroetorphine on mitogen-stimulated lymphocyte proliferation and lymphokine production in mice. These immune functions were significantly suppressed by dihydroetorphine at 24 microg/kg and 128 microg/kg in a dose-dependent fashion. This study further examined the involvement of micro-opioid receptors and alpha-adrenoceptors in the immunomodulatory effects of dihydroetorphine. The micro-opioid receptor antagonist, naloxone (4 mg/kg), and alpha-adrenoceptor antagonist, phentolamine (10 mg/kg), but not the beta-adrenoceptor antagonist, propranolol (10 mg/kg), effectively blocked dihydroetorphine-induced suppression of splenic lymphocyte proliferation and lymphokine production. These results demonstrate that dihydroetorphine has significant immunosuppressive effects in mice and the mechanisms of these effects may lie in its interactions with opioid receptors and adrenergic pathways. |
| Databáze: | OpenAIRE |
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