Additional file 1: Data S1. of The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinsonâ s disease

Autor: Finkelstein, David, Billings, Jessica, Adlard, Paul, Ayton, Scott, Sedjahtera, Amelia, Masters, Colin, Wilkins, Simon, Shackleford, David, Charman, Susan, Bal, Wojciech, Zawisza, Izabela, Kurowska, Ewa, Gundlach, Andrew, Ma, Sheri, Bush, Ashley, Hare, Dominic, Doble, Philip, Crawford, Simon, Gautier, Elisabeth, Parsons, Jack, Huggins, Penny, Barnham, Kevin, Cherny, Robert
Rok vydání: 2017
DOI: 10.6084/m9.figshare.c.3813961_d1.v1
Popis: Potentiometric determination of PBT434 affinity for Fe(III), Fe(II) Cu(II) and Zn(II) Ions. Figure S2. Effect of PBT434 on brain iron and peripheral markers of iron metabolism. Data S3. Pharmacokinetics, pharmacodynamics and safety. Figure S4. Experimental schema. Figure S5. Fe and Cu levels in SNpc (solution ICP-MS). Figure S6. Effect of PBT434 on the phenotype of the transgenic hA53T. (DOCX 4044Â kb)
Databáze: OpenAIRE