Blast crisis supervening on chronic lymphocytic leukaemia. A monoclonal progression of the disease as defined by cell surface markers
| Autor: | J. P. Saint-Andre, G. Renier, Jacques Gardais, M. Boasson, Daniel Hurez, Norbert Ifrah |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty Fluorescent Antibody Technique Disease Immunofluorescence hemic and lymphatic diseases medicine Humans Direct fluorescent antibody Aged medicine.diagnostic_test biology Cluster of differentiation business.industry Lymphoblast Hematology General Medicine medicine.disease Leukemia Lymphoid Leukemia Karyotyping Immunology Monoclonal biology.protein Antibody Blast Crisis business |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1600-0609 0902-4441 |
| DOI: | 10.1111/j.1600-0609.1987.tb00786.x |
| Popis: | Acute leukaemia is a rare event during the course of chronic lymphocytic leukaemia (CLL), and only a small fraction of such cases have been shown to be true acute lymphoblastic crises. 1 case is described where both small lymphocytes and proliferating lymphoblasts have the same monoclonal pattern as defined by direct immunofluorescence of membrane-bound immunoglobulins. Previous cases are reviewed and do not appear to be mere coincidence: acute blast crisis may represent a part of the natural history of CLL. |
| Databáze: | OpenAIRE |
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