Efficient red light photo-uncaging of active molecules in water upon assembly into nanoparticles

Autor:	Mathieu L. Viger, Viet Anh Nguyen Huu, Carl-Johan Carling, Brendan M. Duggan, Guillaume Collet, Jason Olejniczak, Adah Almutairi, Alexandra Foucault-Collet
Rok vydání:	2016
Předmět:	Aqueous solution 010405 organic chemistry Chemistry Nanoparticle Nanotechnology General Chemistry 010402 general chemistry Photochemistry 01 natural sciences Fluorescence 0104 chemical sciences Particle Molecule Red light
Zdroj:	Chemical Science. 7:2392-2398
ISSN:	2041-6539 2041-6520
DOI:	10.1039/c5sc03717d
Popis:	We introduce a means of efficiently photo-uncaging active compounds from amino-1,4-benzoquinone in aqueous environments. Aqueous photochemistry of this photocage with one-photon red light is typically not efficient unless the photocaged molecules are allowed to assemble into nanoparticles. A variety of biologically active molecules were functionalized with the photocage and subsequently formulated into water-dispersible nanoparticles. Red light irradiation through various mammalian tissues achieved efficient photo-uncaging. Co-encapsulation of NIR fluorescent dyes and subsequent photomodulation provides a NIR fluorescent tool to assess both particle location and successful photorelease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7722419039f0220baac2c0796d0c3d85 https://doi.org/10.1039/c5sc03717d Zobrazit plný text záznamu