Structural Studies of a Stapled Peptide with Native Ion Mobility-Mass Spectrometry and Transition Metal Ion Förster Resonance Energy Transfer in the Gas Phase

Autor:	Ri Wu, Jonas B. Metternich, Prince Tiwari, Lukas R. Benzenberg, Julian A. Harrison, Qinlei Liu, Renato Zenobi
Rok vydání:	2022
Předmět:	Ions Colloid and Surface Chemistry Ion Mobility Spectrometry Fluorescence Resonance Energy Transfer Transition Elements General Chemistry Peptides Biochemistry Catalysis Mass Spectrometry
Zdroj:	Journal of the American Chemical Society. 144(32)
ISSN:	1520-5126
Popis:	Native mass spectrometry has emerged as an important tool for gas-phase structural biology. However, the conformations that a biomolecular ion adopts in the gas phase can differ from those found in solution. Herein, we report a synergistic, native ion mobility-mass spectrometry (IM-MS) and transition metal ion Förster resonance energy transfer (tmFRET)-based approach to probe the gas-phase ion structures of a nonstapled peptide (nsp; Ac-CAARAAHAAAHARARA-NH
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7721530c1f35764f80e19ac40ca5494b https://pubmed.ncbi.nlm.nih.gov/35943275 Zobrazit plný text záznamu