High risk factors of pancreatic carcinoma
| Autor: | Dusabe Emmanuel, Jiongxin Xiong, Sonam Ramdany, Naby Laye Moussa Keita, Yao Guo, Jing Tao, Tajoo Aroun, Wei Zhou, Mohamed Cisse, Min Huang, Tao Liu, Namory Keita, Jing Cui, Alpha Kabinet Camara, Ibrahima Sory Souare, Abdoulaye Korse Balde, Chunyou Wang, Bo Wang, Naby Daouda Camara, Zhen Feng, Soriba Naby Camara, Xiang Li, Tenin Conde, Ming Yang, Qiong Gong, Gang Zhao, Martin Kuete, Tao Yin, Zhiyong Yang, Xin Ning, Ohoya Etsaka Terence Olivier, Heshui Wu, Qi Qin, Sneha Ballah, Aissatou Taran Diallo, Jing Zhou, Aboubacar Sidiki Magassouba, Aboubacar Toure, Shanmiao Gou, Sadamoudou Traore |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pathology Alcohol Drinking Biomedical Engineering Disease Bioinformatics Biochemistry ABO Blood-Group System Biomaterials 03 medical and health sciences 0302 clinical medicine Risk Factors Pancreatitis Chronic Pancreatic cancer Epidemiology Diabetes Mellitus Genetics Genetic predisposition medicine Humans Genetic Predisposition to Disease Obesity Pancreas Earth-Surface Processes business.industry Mechanism (biology) Incidence Incidence (epidemiology) Smoking Cancer Prognosis medicine.disease Survival Analysis Pancreatic Neoplasms 030220 oncology & carcinogenesis Etiology Gene-Environment Interaction 030211 gastroenterology & hepatology business Precancerous Conditions |
| Zdroj: | Journal of Huazhong University of Science and Technology [Medical Sciences]. 36:295-304 |
| ISSN: | 1993-1352 1672-0733 |
| DOI: | 10.1007/s11596-016-1583-x |
| Popis: | Over the past decades, cancer has become one of the toughest challenges for health professionals. The epidemiologists are increasingly directing their research efforts on various malignant tumor worldwide. Of note, incidence of cancers is on the rise more quickly in developed countries. Indeed, great endeavors have to be made in the control of the life-threatening disease. As we know it, pancreatic cancer (PC) is a malignant disease with the worst prognosis. While little is known about the etiology of the PC and measures to prevent the condition, so far, a number of risk factors have been identified. Genetic factors, pre-malignant lesions, predisposing diseases and exogenous factors have been found to be linked to PC. Genetic susceptibility was observed in 10% of PC cases, including inherited PC syndromes and familial PC. However, in the remaining 90%, their PC might be caused by genetic factors in combination with environmental factors. Nonetheless, the exact mechanism of the two kinds of factors, endogenous and exogenous, working together to cause PC remains poorly understood. The fact that most pancreatic neoplasms are diagnosed at an incurable stage of the disease highlights the need to identify risk factors and to understand their contribution to carcinogenesis. This article reviews the high risk factors contributing to the development of PC, to provide information for clinicians and epidemiologists. |
| Databáze: | OpenAIRE |
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