Diagnostic Accuracy of CT for Metastatic Epidural Spinal Cord Compression

Autor: James Thomas Patrick Decourcy Hallinan, Shuliang Ge, Lei Zhu, Wenqiao Zhang, Yi Ting Lim, Yee Liang Thian, Pooja Jagmohan, Tricia Kuah, Desmond Shi Wei Lim, Xi Zhen Low, Ee Chin Teo, Nesaretnam Barr Kumarakulasinghe, Qai Ven Yap, Yiong Huak Chan, Jiong Hao Tan, Naresh Kumar, Balamurugan A. Vellayappan, Beng Chin Ooi, Swee Tian Quek, Andrew Makmur
Rok vydání: 2022
Předmět:
Zdroj: Cancers
Volume 14
Issue 17
Pages: 4231
ISSN: 2072-6694
Popis: Background: Early diagnosis of metastatic epidural spinal cord compression (MESCC) is vital to expedite therapy and prevent paralysis. Staging CT is performed routinely in cancer patients and presents an opportunity for earlier diagnosis. Methods: This retrospective study included 123 CT scans from 101 patients who underwent spine MRI within 30 days, excluding 549 CT scans from 216 patients due to CT performed post-MRI, non-contrast CT, or a gap greater than 30 days between modalities. Reference standard MESCC gradings on CT were provided in consensus via two spine radiologists (11 and 7 years of experience) analyzing the MRI scans. CT scans were labeled using the original reports and by three radiologists (3, 13, and 14 years of experience) using dedicated CT windowing. Results: For normal/none versus low/high-grade MESCC per CT scan, all radiologists demonstrated almost perfect agreement with kappa values ranging from 0.866 (95% CI 0.787–0.945) to 0.947 (95% CI 0.899–0.995), compared to slight agreement for the reports (kappa = 0.095, 95%CI −0.098–0.287). Radiologists also showed high sensitivities ranging from 91.51 (95% CI 84.49–96.04) to 98.11 (95% CI 93.35–99.77), compared to 44.34 (95% CI 34.69–54.31) for the reports. Conclusion: Dedicated radiologist review for MESCC on CT showed high interobserver agreement and sensitivity compared to the current standard of care.
Databáze: OpenAIRE
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