ВИВЧЕННЯ АКТИВНОСТІ БІОХІМІЧНИХ ПОКАЗНИКІВ КІСТКОВОГО МЕТАБОЛІЗМУ В НИЖНІХ ЩЕЛЕПАХ, УРАЖЕНИХ РАДИКУЛЯРНИМИ КІСТАМИ, У ХВОРИХ ІЗ РІЗНИМ СТАНОМ МІНЕРАЛЬНОГО ОБМІНУ
| Autor: | O. I. Hrushka, S. T. Havryltsiv, Yu. V. Vovk |
|---|---|
| Jazyk: | ukrajinština |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Osteoporosis лужна фосфатаза lcsh:Medicine Bone tissue Bone resorption Bone remodeling 03 medical and health sciences 0302 clinical medicine радикулярна кіста Internal medicine medicine індекс мінералізації мінеральний обмін нижня щелепа Radicular Cyst biology business.industry кисла фосфатаза lcsh:R Acid phosphatase 030206 dentistry medicine.disease Resorption Endocrinology medicine.anatomical_structure кістковий метаболізм 030220 oncology & carcinogenesis biology.protein Alkaline phosphatase остеопороз business |
| Zdroj: | Vіsnik Naukovih Doslіdžen', Iss 2, Pp 72-77 (2019) |
| ISSN: | 2415-8798 |
| Popis: | In response to growing compression of the increasing volume of radicular cysts from adjacent bone tissue of the jaws, compensatory reorganization of the morphological structure of the spongy substance occurs – its consolidation, which is a morphological manifestation of the local adaptive reaction of the organism. However, in the case of violation of mineral metabolism (osteoporosis) in the bone tissue, morphological changes occur. In postmenopausal women, the expression of alkaline phosphatase decreases on the background of estrogen deficiency, the inhibitory activity of this hormone on osteoclasts is reduced, which is accompanied by an increase in the activity of acid phosphatase and, consequently, an increase in bone resorption. The aim of the study – to carry out a comparative assessment of the activity of biochemical parameters of bone metabolism in the regions of the mandible affected by radicular cysts in patients with a different state of mineral metabolism. Materials and Methods. All patients with radicular cysts of the mandible, depending on the state of mineral metabolism, were divided into two clinical groups: clinical group 1 included 21 patients (13 men and 8 women), in which no age-related violations of mineral metabolism were detected; clinical group 2 included 19 patients (14 women and 5 men), in whom age-related violations of mineral metabolism were detected – osteoporosis. Patients were determined the mineral density of bone tissue by using bone ultrasonic densitometry. On orthopantomograms of the facial skeleton localization and size of radicular cysts were revealed. The state of mineral metabolism in the lower jaw was evaluated on X-ray images by using the mandibular – cortical index (MCI) by Klemetti E. and co-authors. Materials for biochemical studies (determination of activity of alkaline and acid phosphatases, index of mineralization) were obtained by taking bone fragments from regions adjacent to the shells of the radicular cysts of the mandible during cystectomy operations. The statistical processing of the obtained research results was carried out using the statistical program of statistical calculations "Statistica 8". Results and Discussion. In patients with no mineral metabolism disturbances, in bone biopsy samples taken from sites affected by radicular cysts of the mandible, statistically significant (p |
| Databáze: | OpenAIRE |
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