Stochastic parametric skeletal dosimetry model for humans: General approach and application to active marrow exposure from bone-seeking beta-particle emitters

Autor: Elena A. Shishkina, V.I. Zalyapin, Pavel A. Sharagin, Bruce A. Napier, Evgenia I. Tolstykh, Alexandra Yu. Volchkova, Marina O. Degteva, M.A. Smith
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Vertebrae
Computer science
Monte Carlo method
Geometric shape
Bone tissue
Bone Marrow
Bone Density
Materials Physics
Beta particle
Medicine and Health Sciences
Femur
Child
Musculoskeletal System
Microstructure
Parametric statistics
Multidisciplinary
Physics
Human femur
Middle Aged
medicine.anatomical_structure
Connective Tissue
Child
Preschool
Physical Sciences
Medicine
Female
Anatomy
Biological system
Monte Carlo Method
Research Article
Adult
Adolescent
Science
Materials Science
Biophysics
Radiation Dosage
Models
Biological
Bone and Bones
Young Adult
Dosimetry
medicine
Humans
Adults
Computer Simulation
Radiometry
Bone
Skeleton
Aged
Stochastic Processes
Infant
Biology and Life Sciences
Spine
Beta Particles
Hematopoiesis
Biological Tissue
Age Groups
People and Places
Population Groupings
Diaphyses
Bone marrow
Zdroj: PLoS ONE, Vol 16, Iss 10, p e0257605 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: The objective of this study is to develop a skeleton model for assessing active marrow dose from bone-seeking beta-emitting radionuclides. This article explains the modeling methodology which accounts for individual variability of the macro- and microstructure of bone tissue. Bone sites with active hematopoiesis are assessed by dividing them into small segments described by simple geometric shapes. Spongiosa, which fills the segments, is modeled as an isotropic three-dimensional grid (framework) of rod-like trabeculae that “run through” the bone marrow. Randomized multiple framework deformations are simulated by changing the positions of the grid nodes and the thickness of the rods. Model grid parameters are selected in accordance with the parameters of spongiosa microstructures taken from the published papers. Stochastic modeling of radiation transport in heterogeneous media simulating the distribution of bone tissue and marrow in each of the segments is performed by Monte Carlo methods. Model output for the human femur at different ages is provided as an example. The uncertainty of dosimetric characteristics associated with individual variability of bone structure was evaluated. An advantage of this methodology for the calculation of doses absorbed in the marrow from bone-seeking radionuclides is that it does not require additional studies of autopsy material. The biokinetic model results will be used in the future to calculate individual doses to members of a cohort exposed to 89,90Sr from liquid radioactive waste discharged to the Techa River by the Mayak Production Association in 1949–1956. Further study of these unique cohorts provides an opportunity to gain more in-depth knowledge about the effects of chronic radiation on the hematopoietic system. In addition, the proposed model can be used to assess the doses to active marrow under any other scenarios of 90Sr and 89Sr intake to humans.
Databáze: OpenAIRE
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