Regulation and function of interleukin-36 cytokines
| Autor: | Esen Yonca Bassoy, Cem Gabay, Jennifer E. Towne |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Agonist medicine.drug_class Interleukin-1 Receptor Accessory Protein/metabolism medicine.medical_treatment Immunology Biology 03 medical and health sciences 0302 clinical medicine Immune system Arthritis Psoriatic/immunology Fibroblasts/physiology Intestines/pathology/physiology medicine Immunology and Allergy Epithelial Cells/physiology Animals Humans Skin/metabolism/pathology Receptor Skin ddc:616 Inflammation Receptors Interleukin/metabolism Arthritis Psoriatic Antagonist Interleukin-36 Interleukin Epithelial Cells Receptors Interleukin Fibroblasts 3. Good health Intestines 030104 developmental biology Cytokine Interleukin-1/metabolism Interleukin-1 Receptor Accessory Protein Intracellular 030215 immunology Interleukin-1 Protein Binding |
| Zdroj: | Immunological Reviews, Vol. 281, No 1 (2018) pp. 169-178 |
| ISSN: | 1600-065X 0105-2896 |
| Popis: | The interleukin (IL)-36 cytokines include 3 agonists, IL-36α, IL-36β, and IL-36γ that bind to a common receptor composed of IL-36R and IL-1RAcP to stimulate inflammatory responses. IL-36Ra is a natural antagonist that binds to IL-36R, but does not recruit the co-receptor IL-1RAcP and does not stimulate any intracellular responses. The IL-36 cytokines are expressed predominantly by epithelial cells and act on a number of cells including immune cells, epithelial cells, and fibroblasts. Processing of the N-terminus is required for full agonist or antagonist activity for all IL-36 members. The role of IL-36 has been extensively demonstrated in the skin where it can act on keratinocytes and immune cells to induce a robust inflammatory response that has been implicated in psoriatic disorders. Emerging data also suggest a role for this cytokine family in pulmonary and intestinal physiology and pathology. |
| Databáze: | OpenAIRE |
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