Neurocircuit models of obsessive-compulsive disorder
| Autor: | Leonardo Saraiva, Roseli G. Shavitt, H. Blair Simpson, Pedro Fonseca Zuccolo, Carolina Cappi, Carolina Y. Ogawa, Andre R. Brunoni, Victoria Doretto, Euripedes Constantino Miguel, Emily R. Stern, Elizabeth Shephard, Odile A. van den Heuvel, Renata de Melo Felipe da Silva, Marcelo Q. Hoexter, Daniel L. C. Costa, Marcelo C. Batistuzzo |
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| Přispěvatelé: | Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Neurodegeneration |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Psychiatry
neurobiology clinical presentation RC435-571 Neuropsychology treatment advances Treatment method Neuroimaging Cognition behavioral disciplines and activities Psychiatry and Mental health Obsessive compulsive mental disorders Compulsive Behavior Obsessive-compulsive disorder Humans neurocircuit models Obsessive Behavior Psychology Neurocognitive Clinical psychology |
| Zdroj: | Brazilian Journal of Psychiatry (2021) Brazilian Journal of Psychiatry, Volume: 44, Issue: 2, Pages: 187-200, Published: 11 JUN 2021 Brazilian Journal of Psychiatry v.44 n.2 2022 Brazilian Journal of Psychiatry (São Paulo. 1999. Online) Associação Brasileira de Psiquiatria (ABP) instacron:ABP Revista Brasileira de Psiquiatria, 44(2), 187-200. Associacao Brasileira de Psiquiatria Shephard, E, Batistuzzo, M C, Hoexter, M Q, Stern, E R, Zuccolo, P F, Ogawa, C Y, Silva, R M, Brunoni, A R, Costa, D L, Doretto, V, Saraiva, L, Cappi, C, Shavitt, R G, Simpson, H B, van den Heuvel, O A & Miguel, E C 2022, ' Neurocircuit models of obsessive-compulsive disorder : limitations and future directions for research ', Revista Brasileira de Psiquiatria, vol. 44, no. 2, pp. 187-200 . https://doi.org/10.1590/1516-4446-2020-1709 Brazilian Journal of Psychiatry, Issue: ahead, Published: 11 JUN 2021 Brazilian Journal of Psychiatry n.ahead 2021 Revista Brasileira de Psiquiatria |
| ISSN: | 1516-4446 |
| DOI: | 10.1590/1516-4446-2020-1709 |
| Popis: | Obsessive-compulsive disorder (OCD) is a common psychiatric condition classically characterized by obsessions (recurrent, intrusive and unwanted thoughts) and compulsions (excessive, repetitive and ritualistic behaviors or mental acts). OCD is heterogeneous in its clinical presentation and not all patients respond to first-line treatments. Several neurocircuit models of OCD have been proposed with the aim of providing a better understanding of the neural and cognitive mechanisms involved in the disorder. These models use advances in neuroscience and findings from neuropsychological and neuroimaging studies to suggest links between clinical profiles that reflect the symptoms and experiences of patients and dysfunctions in specific neurocircuits. Several models propose that treatments for OCD could be improved if directed to specific neurocircuit dysfunctions, thereby restoring efficient neurocognitive function and ameliorating the symptomatology of each associated clinical profile. Yet, there are several important limitations to neurocircuit models of OCD. The purpose of the current review is to highlight some of these limitations, including issues related to the complexity of brain and cognitive function, the clinical presentation and course of OCD, etiological factors, and treatment methods proposed by the models. We also provide suggestions for future research to advance neurocircuit models of OCD and facilitate translation to clinical application. |
| Databáze: | OpenAIRE |
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