Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea
| Autor: | John B. Keven, Jason Rosado, Moses Laman, Cristian Koepfli, Ingrid Felger, Michelle Katusele, Lina Lorry, Daniela Rodriguez-Rodriguez, Natalie E. Hofmann, Manuel W Hetzel, Freya J. I. Fowkes, Elma Nate, Leanne J. Robinson, Alma Auwan, Mary Salib, Ivo Mueller, Maria Ome-Kaius, James W. Kazura, Stephan Karl, Desmond Gul, Archie C. A. Clements |
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| Přispěvatelé: | Burnet Institute [Melbourne, Victoria], Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Papua New Guinea Institute of Medical Research (PNG-IMR), Michigan State University System, Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), University of Notre Dame [Indiana] (UND), The Walter and Eliza Hall Institute of Medical Research (WEHI), Case Western Reserve University [Cleveland], James Cook University (JCU), Curtin University [Perth], Planning and Transport Research Centre (PATREC), Telethon KIDS Institute, The University of Western Australia (UWA), University of Melbourne, Monash University [Melbourne], This work was funded by WHO/Tropical Disease Research Program grant (WCCPRD4426109 2016/639607), NIH NIAID International Centres of Excellence in Malaria Research South West Pacific (U19 AI089686) and Asia Pacific (U19 AI129392-01) and NHMRC Australian Centre of Research Excellence for Malaria Elimination (ACREME GNT1134989). D.G. is supported by an Australian Government Research Training Program (RTP) Scholarship. M.K. is the recipient of a Wellcome Trust International Masters Fellowship. I.M. (GNT11155075), S.K. (GNT1141441) and L.J.R. (GNT1161627) are supported by NHMRC Fellowships., Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Epidemiology Plasmodium ovale law.invention 0302 clinical medicine law [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Prevalence 030212 general & internal medicine Malaria Falciparum Toilet Facilities 2. Zero hunger Family Characteristics Multidisciplinary Mosquito Nets Coinfection New guinea 3. Good health Spatial heterogeneity Geography Transmission (mechanics) Medicine Female medicine.medical_specialty Science 030231 tropical medicine Article 03 medical and health sciences Papua New Guinea Age Distribution Malaria elimination Environmental health parasitic diseases medicine Malaria Vivax Humans Ecosystem Disease Reservoirs Construction Materials Drinking Water Odds ratio 15. Life on land medicine.disease Health Surveys Malaria Cross-Sectional Studies Social Class Risk factors Vector (epidemiology) [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.16540. ⟨10.1038/s41598-021-95959-8⟩ Scientific Reports, 2021, 11 (1), pp.16540. ⟨10.1038/s41598-021-95959-8⟩ Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-95959-8⟩ |
| Popis: | Malaria risk is highly heterogeneous. Understanding village and household-level spatial heterogeneity of malaria risk can support a transition to spatially targeted interventions for malaria elimination. This analysis uses data from cross-sectional prevalence surveys conducted in 2014 and 2016 in two villages (Megiar and Mirap) in Papua New Guinea. Generalised additive modelling was used to characterise spatial heterogeneity of malaria risk and investigate the contribution of individual, household and environmental-level risk factors. Following a period of declining malaria prevalence, the prevalence of P. falciparum increased from 11.4 to 19.1% in Megiar and 12.3 to 28.3% in Mirap between 2014 and 2016, with focal hotspots observed in these villages in 2014 and expanding in 2016. Prevalence of P. vivax was similar in both years (20.6% and 18.3% in Megiar, 22.1% and 23.4% in Mirap) and spatial risk heterogeneity was less apparent compared to P. falciparum. Within-village hotspots varied by Plasmodium species across time and between villages. In Megiar, the adjusted odds ratio (AOR) of infection could be partially explained by household factors that increase risk of vector exposure, such as collecting outdoor surface water as a main source of water. In Mirap, increased AOR overlapped with proximity to densely vegetated areas of the village. The identification of household and environmental factors associated with increased spatial risk may serve as useful indicators of transmission hotspots and inform the development of tailored approaches for malaria control. |
| Databáze: | OpenAIRE |
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