Infusion of flesinoxan into the amygdala blocks the fear-potentiated startle
| Autor: | Lucianne Groenink, Anneloes Dirks, Rosemarie J. E. Joordens, Theo H. Hijzen, Berend Olivier |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Reflex Startle Startle response Median raphe nucleus Fear-potentiated startle Functional Laterality Piperazines Dorsal raphe nucleus Flesinoxan medicine Animals Infusions Parenteral Rats Wistar Dose-Response Relationship Drug medicine.diagnostic_test General Neuroscience Central nucleus of the amygdala Fear Amygdala Startle reaction Rats Anti-Anxiety Agents Receptors Serotonin Raphe Nuclei Raphe nuclei Psychology Receptors Serotonin 5-HT1 Neuroscience medicine.drug |
| Zdroj: | NeuroReport. 11:2285-2288 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200007140-00043 |
| Popis: | In a previous study it was demonstrated that flesinoxan, a selective serotonin (5-HT)1A receptor agonist, had anxiolytic properties in the fear-potentiated startle paradigm. The present study investigated the putative site of action of flesinoxan in this paradigm. Flesinoxan infused either into the dorsal raphe nucleus or the median raphe nucleus did not affect startle potentiation. Bilateral infusion of flesinoxan into the central nucleus of the amygdala on the other hand, dose-dependently blocked the fear-potentiated startle response. These data indicate that flesinoxan exerts it anxiolytic effects in the fear-potentiated startle paradigm via the central nucleus of the amygdala, whereas the dorsal and median raphe nuclei are not directly involved in this process. |
| Databáze: | OpenAIRE |
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