High frequency of fusion gene transcript resulting from t(10;11)(p12;q23) translocation in pediatric acute myeloid leukemia in Poland
| Autor: | Przemyslaw Kaczowka, Katarzyna Muszyńska-Rosłan, Elżbieta Adamkiewicz-Drożyńska, Maryna Krawczuk-Rybak, Alicja Chybicka, Teofila Ksiazek, Lucyna Maciejka-Kemblowska, Monika Lejman, Anna Rodziewicz-Konarska, Miroslaw Bik-Multanowski, Jacek Wachowiak, Jerzy Kowalczyk, Joanna Pohorecka, Irena Karpińska-Derda, Agnieszka Mizia-Malarz, Jolanta Skalska-Sadowska, Wojciech Młynarski, Małgorzata Ciebiera, Grażyna Karolczyk, Tomasz Urasiński, Katarzyna Pawinska-Wasikowska, Tomasz Szczepański, Walentyna Balwierz, Beata Sadowska, Mariola Woszczyk, Szymon Skoczeń, Katarzyna Mycko, Barbara Sikorska-Fic, Małgorzata Czogała, Karolina Zielezińska, Wanda Badowska, Michał Matysiak, Dominik Grabowski, Renata Tomaszewska |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Chromosomal translocation
risk stratification acute myeloid leukemia 11q23/KMT2A rearrangements 030204 cardiovascular system & hematology Pediatrics Fusion gene 03 medical and health sciences 0302 clinical medicine children hemic and lymphatic diseases 030225 pediatrics Medicine Clinical significance neoplasms Original Research Pediatric leukemia Acute leukemia biology business.industry Pediatric acute myeloid leukemia lcsh:RJ1-570 MLL rearrangements lcsh:Pediatrics medicine.disease Lymphoma treatment results KMT2A Pediatrics Perinatology and Child Health biology.protein Cancer research business |
| Zdroj: | Frontiers in Pediatrics Frontiers in Pediatrics, Vol 8 (2020) |
| Popis: | 11q23/MLL rearrangements are frequently detected in pediatric acute myeloid leukemia. The analysis of their clinical significance is difficult because of the multitude of translocation fusion partners and their low frequency. The presence of t(10;11)(p12;q23) translocation was previously identified in pediatric acute myelogenous leukemia (AML). It is considered as the second most common translocation detected in pediatric 11q23/MLL-rearranged (present KMT2A) AML, after t(9;11)(p22;q23). The presence of the above translocation was previously identified as an unfavorable prognostic factor. Since June 2015, the Polish Pediatric Leukemia/Lymphoma Study Group has applied the therapeutic protocol requiring extensive diagnostics of genetic changes in pediatric AML. Until November 2019, molecular genetic studies were performed in 195 children with diagnosed AML to identify carriers of fusion gene transcripts for 28 most common chromosomal translocations in acute leukemia. The fusion gene transcript for translocation t(10;11)(p12;q23) involving MLL gene was detected with unexpectedly high frequency (8.9%) in our research. It was the highest frequency of all detected MLL rearrangements, as well as other detected fusion gene transcripts from chromosomal aberrations characteristic for AML. It seems that chromosomal aberration between chromosomes 10 and 11 can be relatively frequent in some populations. Paying attention to this fact and ensuring proper genetic diagnosis seem to be important for appropriate allocation of patients to risk groups of pediatric AML treatment protocols. |
| Databáze: | OpenAIRE |
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