Measuring quality of life in ALS/MND: validation of the WHOQOL-BREF
| Autor: | Carolyn A Young, Ashwin Pinto, G Burke, Tim Williams, Ammar Al-Chalabi, Kevin Talbot, Jannette Walsh, Roger J Mills, Christopher J McDermott, Tahir Majeed, C. Oliver Hanemann, Siddharthan Chandran, Timothy Harrower, John Ealing, Alan Tennant, David Dick |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
education.field_of_study
Rasch model Population Construct validity Contrast (statistics) Differential item functioning humanities 03 medical and health sciences 0302 clinical medicine Neurology Quality of life Scale (social sciences) Observational study Neurology (clinical) Psychology education 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Young, C A, Mills, R, Al-chalabi, A, Burke, G, Chandran, S, Dick, D J, Ealing, J, Hanemann, C O, Harrower, T, Mcdermott, C J, Majeed, T, Pinto, A, Talbot, K, Walsh, J, Williams, T L & Tennant, A 2020, ' Measuring quality of life in ALS/MND: validation of the WHOQOL-BREF ', Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, pp. 1-9 . https://doi.org/10.1080/21678421.2020.1752244 |
| Popis: | Objectives: The World Health Organization Quality of Life-BREF Scale (WHOQOL-BREF) is a generic QOL measure with four domains covering Physical, Psychological, Social and Environment. Providing the opportunity to contrast QoL with other conditions, or with population norms, the current study had three aims: 1) can the established domains of the WHOQOL-BREF be validated within a large ALS/MND population; 2) can a total score be validated and 3) can they provide interval level measurement? Methods: Data were obtained from the Trajectories of Outcomes in Neurological Conditions study. Internal construct validity was determined by fit of the data to the Rasch measurement model. Results: 636 participants with ALS/MND were included. All domains, except the Social domain, showed satisfactory fit to the Rasch model. All were unidimensional, and showed no Differential Item Functioning by age, gender, or onset type. Finally, a total score was validated from a bi-factor perspective. Conclusions: The WHOQOL-BREF is valid for use in populations with ALS/MND and can be analyzed to yield interval level measurement: It offers a range of domains that reflect QOL, which can be used for parametric analysis and for comparison with other conditions or general populations, two advantages for its inclusion as a trial outcome measure and for observational studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|