Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke
| Autor: | Isabelle Loubinoux, Claude Manelfe, Christophe Carel, Jean-François Albucher, Olivier Rascol, François Chollet, Anne Leger, Jérémie Pariente |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Brain Infarction Male medicine.medical_specialty Lacunar stroke Placebos Double-Blind Method Fluoxetine medicine Humans Prospective Studies Stroke Motor skill Aged Cross-Over Studies Cerebral infarction Brain Recovery of Function Middle Aged medicine.disease Magnetic Resonance Imaging Surgery Hemiparesis medicine.anatomical_structure Neurology Motor Skills Anesthesia Female Neurology (clinical) Primary motor cortex medicine.symptom Psychology Selective Serotonin Reuptake Inhibitors Motor cortex medicine.drug |
| Zdroj: | Annals of Neurology. 50:718-729 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.1257 |
| Popis: | In order to determine the influence of a single dose of fluoxetine on the cerebral motor activation of lacunar stroke patients in the early phase of recovery, we conducted a prospective, double-blind, crossover, placebo-controlled study on 8 patients with pure motor hemiparesia. Each patient underwent two functional magnetic resonance imaging (fMRI) examinations: one under fluoxetine and one under placebo. The first was performed 2 weeks after stroke onset and the second a week later. During the two fMRI examinations, patients performed an active controlled motor task with the affected hand and a passive one conducted by the examiner with the same hand. Motor performance was evaluated by motor tests under placebo and under fluoxetine immediately before the examinations to investigate the effect of fluoxetine on motor function. Under fluoxetine, during the active motor task, hyperactivation in the ipsilesional primary motor cortex was found. Moreover, fluoxetine significantly improved motor skills of the affected side. We found that a single dose of fluoxetine was enough to modulate cerebral sensory-motor activation in patients. This redistribution of activation toward the motor cortex output activation was associated with an enhancement of motor performance. |
| Databáze: | OpenAIRE |
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