The action of orexin B on passive avoidance learning. Involvement of neurotransmitters
| Autor: | Gyula Telegdy, Miklos Palotai, Alphonsus Ekwerike, Miklós Jászberényi |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Adrenergic Antagonists medicine.drug_class Narcotic Antagonists (+)-Naloxone Synaptic Transmission Behavioral Neuroscience Orexin-A Memory Orexin Receptors Orexigenic Receptors Adrenergic beta mental disorders Avoidance Learning medicine Animals GABA-A Receptor Antagonists Rats Wistar Neurotransmitter Agents Orexins Receptors Dopamine D2 Neuropeptides Receptors Dopamine D4 digestive oral and skin physiology Intracellular Signaling Peptides and Proteins Receptors Dopamine D3 Receptors Adrenergic alpha Bicuculline Receptors GABA-A Receptor antagonist Orexin receptor Orexin nervous system Receptors Opioid Dopamine Antagonists Orexin Receptor Antagonists Memory consolidation Nitric Oxide Synthase Psychology Neuroscience hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Behavioural Brain Research. 272:1-7 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2014.06.016 |
| Popis: | The extensive projection of orexigenic neurons and the diffuse expression of orexin receptors suggest that endogenous orexins are involved in several physiological functions of the central nervous system, including learning and memory. Our previous study demonstrated that orexin A improves learning, consolidation and retrieval processes, which involves α- and β-adrenergic, cholinergic, dopaminergic, GABA-A-ergic, opiate and nitrergic neurotransmissions. However, we have little evidence about the action of orexin B on memory processes and the underlying neuromodulation. Therefore, the aim of the present study was to investigate the action of orexin B on passive avoidance learning and the involvement of neurotransmitters in this action in rats. Accordingly, rats were pretreated with the selective orexin 2 receptor (OX2R) antagonist, EMPA; the γ-aminobutyric acid subunit A (GABA-A) receptor antagonist, the bicuculline; a D2, D3, D4 dopamine receptor antagonist, haloperidol; the nonselective opioid receptor antagonist, naloxone; the non-specific nitric oxide synthase (NOS) inhibitor, nitro-l-arginine; the nonselective α-adrenergic receptor antagonist, phenoxybenzamine and the β-adrenergic receptor antagonist, propranolol. Our results demonstrate that orexin B can improve learning, consolidation of memory and retrieval. EMPA reversed completely the action of orexin B on memory consolidation. Bicuculline blocked fully; naloxone, nitro-l-arginine, phenoxybenzamine and propranolol attenuated the orexin B-induced memory consolidation, whereas haloperidol was ineffective. These data suggest that orexin B improves memory functions through OX2R and GABA-ergic, opiate, nitrergic, α- and β-adrenergic neurotransmissions are also involved in this action. |
| Databáze: | OpenAIRE |
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