Molecular Biology and Evolution of Cancer: From Discovery to Action
| Autor: | Jeffrey Nicholas Fisk, Heather L. Gardner, Alex Dornburg, Kate Megquier, Norman A. Johnson, Amy M. Boddy, Jason A. Somarelli, Sudhir Kumar, Vincent L. Cannataro, Jeffrey H. Chuang, Stephen G. Gaffney, Francesca D. Ciccarelli, Jeffrey P. Townsend, Sheng Li, James DeGregori, Anna R. Panchenko, Ella F. Gunady |
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| Přispěvatelé: | von Haeseler, Arndt |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Process (engineering)
Fitness landscape Evolution comparative oncology fitness landscapes Genomics Biology Ecological systems theory tumor phylogenetics Metastasis Evolution Molecular 03 medical and health sciences 0302 clinical medicine Rare Diseases Neoplasms Breast Cancer medicine Genetics cancer metastasis Humans Stem Cell Niche Molecular Biology Ecology Evolution Behavior and Systematics Phylogeny 030304 developmental biology Cognitive science 0303 health sciences Evolutionary Biology Cancer Molecular medicine.disease Primary tumor 3. Good health Action (philosophy) 030220 oncology & carcinogenesis Perspective Disease Progression Biochemistry and Cell Biology Genetic Fitness |
| Zdroj: | Molecular Biology and Evolution Molecular biology and evolution, vol 37, iss 2 |
| ISSN: | 1537-1719 0737-4038 |
| Popis: | Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution—and progression—require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer. |
| Databáze: | OpenAIRE |
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