Reprogramming cancer cells: overview & current progress
| Autor: | Hui Xin Teh, Kian Lam Lim, Soon Keng Cheong, Tunku Kamarul, Hoon Koon Teoh, Pei Feng Choong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Induced Pluripotent Stem Cells Clinical Biochemistry Antineoplastic Agents Disease Biology Epigenesis Genetic 03 medical and health sciences Neoplasms Drug Discovery medicine Animals Humans Epigenetics Induced pluripotent stem cell Epigenesis Pharmacology business.industry Cancer Genetic Therapy Cellular Reprogramming medicine.disease Biotechnology 030104 developmental biology Cancer cell Cancer research Stem cell business Reprogramming Transcription Factors |
| Zdroj: | Expert Opinion on Biological Therapy. 16:941-951 |
| ISSN: | 1744-7682 1471-2598 |
| Popis: | Cancer is a disease with genetic and epigenetic origins, and the possible effects of reprogramming cancer cells using the defined sets of transcription factors remain largely uninvestigated. In the handful of publications available so far, findings have shown that reprogramming cancer cells changed the characteristics of the cells to differ from the parental cancer cells. These findings indicated the possibility of utilizing reprogramming technology to create a disease model in the laboratory to be used in studying the molecular pathogenesis or for drug screening of a particular cancer model.Despite numerous methods employed in generating induced pluripotent stem cells (iPSCs) from cancer cells only a few studies have successfully reprogrammed malignant human cells. In this review we will provide an overview on i) methods to reprogram cancer cells, ii) characterization of the reprogrammed cancer cells, and iii) the differential effects of reprogramming on malignancy, epigenetics and response of the cancer cells to chemotherapeutic agents.Continued technical progress in cancer cell reprogramming technology will be instrumental for more refined in vitro disease models and ultimately for the development of directed and personalized therapy for cancer patients in the future. |
| Databáze: | OpenAIRE |
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