An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety
| Autor: | Maurizio Ciofalo, Renzo Rossi |
|---|---|
| Přispěvatelé: | Renzo Rossi, Maurizio Ciofalo |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
imidazoles
molecular hybrids molecular conjugates antibacterials antibiotic resistance synthesis bioactivity antibiotics antibiotic resistance synthesis medicine.drug_class Antibiotics Pharmaceutical Science Review Microbial Sensitivity Tests 010402 general chemistry 01 natural sciences antibiotics Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Antibiotic resistance lcsh:Organic chemistry Drug Discovery Drug Resistance Bacterial medicine Imidazole Moiety Physical and Theoretical Chemistry antibacterials molecular conjugates Bacteria 010405 organic chemistry molecular hybrids Organic Chemistry Imidazoles Settore CHIM/06 - Chimica Organica Bacterial Infections Antimicrobial Combinatorial chemistry Settore CHIM/08 - Chimica Farmaceutica 0104 chemical sciences Anti-Bacterial Agents chemistry Chemistry (miscellaneous) bioactivity Molecular Medicine Antibacterial activity Linker Conjugate |
| Zdroj: | Molecules Molecules, Vol 25, Iss 5133, p 5133 (2020) |
| ISSN: | 1420-3049 |
| Popis: | The rapid growth of serious infections caused by antibiotic resistant bacteria, especially the nosocomial ESKAPE pathogens, has been acknowledged by Governments and scientists and is one of the world’s major health problems. Various strategies have been and are currently investigated and developed to reduce and/or delay the bacterial resistance. One of these strategies regards the design and development of antimicrobial hybrids and conjugates. This unprecedented critical review, in which our continuing interest in the synthesis and evaluation of the bioactivity of imidazole derivatives is testified, aims to summarise and comment on the results obtained from the end of the 1900s until February 2020 in studies conducted by numerous international research groups on the synthesis and evaluation of the antibacterial properties of imidazole-based molecular hybrids and conjugates in which the pharmacophoric constituents of these compounds are directly covalently linked or connected through a linker or spacer. In this review, significant attention was paid to summarise the strategies used to overcome the antibiotic resistance of pathogens whose infections are difficult to treat with conventional antibiotics. However, it does not include literature data on the synthesis and evaluation of the bioactivity of hybrids and conjugates in which an imidazole moiety is fused with a carbo- or heterocyclic subunit. |
| Databáze: | OpenAIRE |
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