Serological signatures of declining exposure following intensification of integrated malaria control in two rural Senegalese communities
| Autor: | Cheikh Sokhna, Amele Nyedzie Wotodjo, Oumy Niass, Inès Vigan-Womas, Awa Sidibé, Babacar Mbengue, Cheikh Loucoubar, Jean-François Trape, Ronald Perraut, Adama Tall, Odile Mercereau-Puijalon, Marie-Louise Varela, Aissatou Touré, Vincent Richard |
|---|---|
| Přispěvatelé: | Institut Pasteur de Dakar, Réseau International des Instituts Pasteur (RIIP), Institut de recherche pour le développement (IRD [Sénégal]), Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Unité d'immunologie des maladies infectieuses [Antananarivo, Madagascar] (IPM), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors, Institut Pasteur [Paris], The work was supported by grants from the Institut Pasteur Foundation, the prix Jacques Piraud of the Fondation pour la Recherche Médicale and grants from Institut Pasteur ACIP 25_2012 and from the Rotary International associated with the Rotary Paris Alliance and Rotary Dakar Almadies, We are particularly grateful to Dr Shirley Longacre (Vaximax, Paris) who generously provided the PfMSP1p19. We thank Micheline Guillotte-Blisnick for characterizing purity and stability of the recombinant antigens, Pr Alioune Dieye for laboratory support, Dr Makhtar Niang for PCR results and Joseph Faye for Dielmo/Ndiop database management. We thank gratefully all villagers from Dielmo and Ndiop for their generous and committed long-term participation to the study., Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Institut Pasteur de Dakar - Réseau International des Instituts Pasteur (RIIP), Centre National de la Recherche Scientifique (CNRS) - IFR48 - Institut National de la Santé et de la Recherche Médicale (INSERM) - Aix Marseille Université (AMU) - Institut de Recherche pour le Développement (IRD), Institut Pasteur de Madagascar - Réseau International des Instituts Pasteur (RIIP), Département Parasites et Insectes vecteurs, The work was supported by grants from the Institut Pasteur Foundation, the prix Jacques Piraud of the Fondation pour la Recherche Médicale and grants from Institut Pasteur ACIP 25_2012 and from the Rotary International associated with the Rotary Paris Alliance and Rotary Dakar Almadies., VIGAN-WOMAS, Inès |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Rural Population Antibodies Protozoan Antibody Response Salivary Glands law.invention 0302 clinical medicine MESH: Rural Population [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Child MESH: Animals Enzyme-Linked Immunoassays lcsh:Science Child Immune Response Protozoans MESH: Immunoglobulin G Malarial Parasites 3. Good health [SDV] Life Sciences [q-bio] Transmission (mechanics) [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology MESH: Young Adult Cohort MESH: Salivary Glands Plasmodium falciparum Immunology Antigens Protozoan MESH: Host-Parasite Interactions 03 medical and health sciences MESH: Cross-Sectional Studies Antigen MESH: Senegal MESH: Anopheles gambiae Humans Immunoassays MESH: Prevalence MESH: Adolescent MESH: Humans lcsh:R Organisms Biology and Life Sciences MESH: Adult [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology MESH: Rural Health medicine.disease Tropical Diseases 030104 developmental biology Cross-Sectional Studies lcsh:Q Population Groupings Parasitology Apicomplexa MESH: Female Malaria MESH: Antigens Protozoan 0301 basic medicine Plasmodium Anopheles gambiae lcsh:Medicine Rural Health [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity Serology Cohort Studies MESH: Health Surveys law [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] Prevalence Medicine and Health Sciences Malaria Falciparum MESH: Cohort Studies MESH: Plasmodium falciparum Multidisciplinary biology MESH: Malaria Falciparum MESH: Enzyme-Linked Immunosorbent Assay Senegal Infectious Diseases [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases Female [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology Research Article Adult Adolescent Infectious Disease Control Holoendemic 030231 tropical medicine Enzyme-Linked Immunosorbent Assay Research and Analysis Methods Host-Parasite Interactions Young Adult Environmental health Anopheles Parasite Groups medicine Parasitic Diseases Animals MESH: Antibodies Protozoan [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity biology.organism_classification Health Surveys Parasitic Protozoans MESH: Male [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Age Groups Immunoglobulin G People and Places Immunologic Techniques [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2017, 12 (6), pp.e0179146. ⟨10.1371/journal.pone.0179146⟩ PLoS ONE, 2017, 12 (6), pp.e0179146. ⟨10.1371/journal.pone.0179146⟩ PLoS ONE, Vol 12, Iss 6, p e0179146 (2017) PLoS ONE, Public Library of Science, 2017, 12 (6), pp.e0179146. 〈10.1371/journal.pone.0179146〉 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0179146⟩ |
| Popis: | International audience; Recent control scale-up has reduced malaria in many areas but new tools are needed to monitor further progress, including indicators of decreasing exposure to parasite infection. Although serology is considered a promising approach in this regard, the serological impact of control interventions has been so far studied using indirect quantification of exposure. Cohort surveys concomitantly recording entomological and malariometric indices have been conducted in two Senegalese settings where supervised control intensification implemented in 2006 shifted malaria from historically holoendemic in Dielmo and mesoendemic in Ndiop to hypoendemic in both settings by 2013. We analyse here serological signatures of declining transmission using archived blood samples. Responses against ten pre-erythrocytic and erythrocytic antigens from Plasmodium falciparum and P. malariae alongside an Anopheles gambiae salivary gland antigen were analysed. Cross-sectional surveys conducted before (2002) and after (2013) control intensification showed a major impact of control intensification in both settings. The age-associated prevalence, magnitude and breadth of the IgG responses to all antigens were village-specific in 2002. In 2013, remarkably similar patterns were observed in both villages, with marginal responses against all parasite antigens in the 0-5y children and reduced responses in all previously seropositive age groups. Waning of humoral responses of individuals who were immune at the time of control intensification was studied from 2006 to 2013 using yearly samplings. Longitudinal data were analysed using the Cochran-Armittage trend test and an age-related reversible catalytic conversion model. This showed that the antigen-specific antibody declines were more rapid in older children than adults. There was a strong association of antibody decline with the declining entomological inoculation rate. We thus identified serological markers of declining exposure to malaria parasites that should help future monitoring of progress towards malaria elimination. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|