Mitochondrial Dynamics and Apoptosis: A Painful Separation
| Autor: | Dominic I. James, Jean-Claude Martinou |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Programmed cell death
Mitochondrial Proteins/metabolism Cell Apoptosis Mitochondrion Mitochondrial fragmentation General Biochemistry Genetics and Molecular Biology Mitochondrial Proteins Cytochromes c/metabolism ddc:570 medicine Animals Molecular Biology Proto-Oncogene Proteins c-bcl-2/genetics/metabolism Mitochondria/metabolism/ultrastructure biology Cytoskeletal Proteins/metabolism Cytochrome c Cytochromes c Apoptosis/physiology Cell Biology Mitochondria Cell biology Cytoskeletal Proteins medicine.anatomical_structure Mitochondrial structure Proto-Oncogene Proteins c-bcl-2 biology.protein Developmental Biology |
| Zdroj: | Developmental cell, Vol. 15, No 3 (2008) pp. 341-3 |
| ISSN: | 1534-5807 1878-1551 |
| DOI: | 10.1016/j.devcel.2008.08.011 |
| Popis: | Reporting in Molecular Cell, Sheridan et al. (2008) and Breckenridge et al. (2008) show that mitochondrial fragmentation is not required to induce cell death. Meanwhile, Yamaguchi et al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through Opa1-mediated cristae remodeling. Therefore, the connection between mitochondrial structure and apoptosis is more complex than previously imagined. |
| Databáze: | OpenAIRE |
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