Microneedle Array Patch (MAP) Consisting of Crosslinked Hyaluronic Acid Nanoparticles for Processability and Sustained Release
| Autor: | Dae-Sung Kim, Jun-Tae Choi, Yu-Ra Shin, Jung-Hwan Park, Jae Myun Lee, Pil Gu Park, Cheong Bi Kim, Hyemi Kim |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Biocompatibility Swine Pharmaceutical Science Nanoparticle 02 engineering and technology Punctures Administration Cutaneous 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Drug Delivery Systems Hyaluronic acid Rhodamine B Animals Pharmacology (medical) Porcine skin Hyaluronic Acid Dissolution Skin Pharmacology Drug Carriers Mice Inbred BALB C Organic Chemistry technology industry and agriculture Penetration (firestop) 021001 nanoscience & nanotechnology Drug Liberation chemistry Needles Drug delivery Molecular Medicine Nanoparticles 0210 nano-technology Biotechnology Biomedical engineering |
| Zdroj: | Pharmaceutical research. 37(3) |
| ISSN: | 1573-904X |
| Popis: | Crosslinked hyaluronic acid (X-linked HA) is not suitable for making microneedles because of the low fluidity of X-linked HA hydrogel. Microneedles were fabricated using X-linked HA nanoparticles (X-linked HA-NPs) to utilize the sustained drug delivery capability of X-linked HA-NPs and to obtain the processability advantages of X-linked HA. The puncture performance of a microneedle array patch (MAP) made of crosslinked hyaluronic acid nanoparticles (X-linked HA-NP-MAP) was evaluated by insertion in vitro into porcine skin. After a predetermined attachment time, the remaining height of the X-linked HA-NP-MAP was measured to determine the dissolution rate. X-linked HA-NP-MAP and free HA-MAP containing Rhodamine B isothiocyanate-dextran were administered into the back skin of mice, and the relative fluorescent intensity in the back skin was measured over time. The puncture performance of the X-linked HA-NP-MAP was over 90%. The diameter of redispersed X-linked HA-NPs was same as that of the premolded X-linked HA-NPs. The dissolution rate was not different from that of free HA-MAP. In an in vivo experiment, X-linked HA-NP-MAP was administered into the mouse’s back skin successfully and the relative fluorescent intensity of X-linked HA-NP-MAP lasted longer than that of HA-MAP. X-linked HA-NPs provide the biocompatibility, the processability of micromolding, sustained drug release, successful penetration into the skin, and relatively short insertion time for full disintegration of NPs in the skin. X-linked HA-NP-MAP can be used for various applications that require several days of sustained drug release. |
| Databáze: | OpenAIRE |
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