Remote Myocardial Injury: The Protective Role of Fluoxetine
| Autor: | Hafize Uzun, Hayriye Erman, Nermin Yelmen, Ibrahim Guner, Mukaddes Pala, Gulderen Sahin, Mukaddes Esrefoglu, Onur M. Yaman, Remise Gelisgen, Olgu Enis Tok, Uğur Aksu |
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| Přispěvatelé: | EŞREFOĞLU, MUKADDES, Biruni Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Lipid Peroxides Infrarenal abdominal aorta Cardiotonic Agents Oxidant/Anti-Oxidant Balance Physiology Iron Inflammation medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants Rats Sprague-Dawley 03 medical and health sciences Acute Cardiac Injury Physiology (medical) Fluoxetine medicine Animals Creatine Kinase Peroxidase Ischemia-Reperfusion Pharmacology business.industry Myocardium Hemodynamics Infrarenal Abdominal Aorta General Medicine Aortic surgery Oxidants Oxidative Stress 030104 developmental biology Anesthesia Reperfusion Injury The Protective Role of Fluoxetine- CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY cilt.3 ss.1-22 2017 [Yaman O. Erman H. Güner İ. TOK O. E. EŞREFOĞLU M. Pala M. Gelisgen R. Uzun H. Uğur A. Yelmen N. et al. -Remote Myocardial Injury] Cytokines medicine.symptom business Oxidation-Reduction Oxidative stress Biomarkers medicine.drug |
| Popis: | Aortic cross-clamping-induced ischemia–reperfusion (IR) is an important factor in the development of postoperative acute cardiac injury following abdominal aortic surgery. We investigated the possible anti-oxidant/anti-inflammatory effects of fluoxetine (FLX), which is used widely as a preoperative anxiolytic on cardiac injury induced by IR of the infrarenal abdominal aorta. FLX was administered to IR-performed (60 min of ischemia and 120 min of reperfusion) rats for 3 days, once daily at 20 mg/kg i.p. dosage. Results were compared to control and non-FLX-treated IR-performed rats. Serum creatine kinase (CK) and CK-MB levels, lipid hydroperoxide, thiobarbituric acid reactive substances, and pro-oxidant/anti-oxidant balance levels in the IR group were significantly higher whereas superoxide dismutase activity, glutathione, and ferric reducing/anti-oxidant power levels were lower than for the control. IR also increased myeloperoxidase activity, tumor necrosis factor-α, interleukin-1β, and interleukin-6 and decreased interleukin-10 levels. FLX decreased CK, CK-MB, lipid hydroperoxide, thiobarbituric acid reactive substances, and pro-oxidant/anti-oxidant balance levels while increasing superoxide dismutase activity, glutathione, and ferric reducing/anti-oxidant power levels. FLX also decreased myeloperoxidase activity, tumor necrosis factor-α, interleukin-1β, and interleukin-6 levels and increased interleukin-10 levels compared to IR. FLX attenuated the morphological changes associated with cardiac injury. Our study clearly demonstrates that FLX confers protection against aortic IR-induced cardiac injury, tissue leucocyte infiltration, and cellular integrity via its anti-oxidant/anti-inflammatory effects. |
| Databáze: | OpenAIRE |
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