Effects of milrinone on complex ventricular arrhythmias in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
| Autor: | Peter L. Friedman, Wilson S. Colucci, P L Ludmer, D F Gauthier, Michael B. Rocco, Elliott M. Antman, Donald S. Baim |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male medicine.medical_specialty Time Factors Pyridones medicine.medical_treatment Cardiomyopathy Coronary Disease Ventricular tachycardia Severity of Illness Index Sudden cardiac death Electrocardiography Internal medicine Idiopathic dilated cardiomyopathy medicine Ambulatory Care Humans cardiovascular diseases Aged Chemotherapy business.industry Hemodynamics Arrhythmias Cardiac Middle Aged medicine.disease Anesthesia Heart failure Ambulatory cardiovascular system Cardiology Milrinone Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American journal of cardiology. 59(15) |
| ISSN: | 0002-9149 |
| Popis: | To determine whether oral milrinone therapy has an effect on complex ventricular arrhythmias in patients with severe congestive heart failure and, if so, whether a change in the severity of complex ventricular arrhythmias after 1 week of milrinone therapy is associated with a change in the mode or frequency of cardiac mortality, a retrospective analysis was performed to determine the frequency of ventricular tachycardia and the density of ventricular couplets on 24-hour ambulatory electrocardiographic recordings performed before and 1 week after initiation of oral milrinone therapy in 74 consecutive patients with New York Heart Association functional class III or IV congestive heart failure. The endpoints of mortality and mode of death were assessed during a mean follow-up of 6 months. In 91% of the patients, 1 week of oral milrinone therapy was associated with no significant change (85%) or a significant decrease (6%) in the density of ventricular couplets and frequency of ventricular tachycardia. However, in 9% of patients the frequency of complex ventricular arrhythmias increased significantly at the end of 1 week of oral milrinone therapy. In this subgroup, neither total cardiac mortality nor the incidence of sudden cardiac death was significantly higher than that in patients with no change or a decrease in complex ventricular ectopic activity. |
| Databáze: | OpenAIRE |
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