Dehydroepiandrosterone (DHEA) Response to i.v. ACTH in Patients with Chronic Fatigue Syndrome
| Autor: | E. Van Steenberge, Brigitte Velkeniers, Johan Smitz, Isabelle Campine, K. De Meirleir, Erika Joos, P. De Becker |
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| Přispěvatelé: | Department of Embryology and Genetics, Vrije Universiteit Brussel |
| Rok vydání: | 1999 |
| Předmět: |
Adult
musculoskeletal diseases endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Dehydroepiandrosterone Stimulation Adrenocorticotropic hormone Biochemistry Basal (phylogenetics) Endocrinology Adrenocorticotropic Hormone Internal medicine Adrenal Glands medicine Chronic fatigue syndrome Humans In patient Fatigue Syndrome Chronic business.industry Biochemistry (medical) General Medicine medicine.disease business human activities hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug Hormone |
| Zdroj: | Hormone and Metabolic Research. 31:18-21 |
| ISSN: | 1439-4286 0018-5043 |
| Popis: | Previous studies have demonstrated concentrating neuroendocrinological disturbances in chronic fatigue syndrome (CFS) patients, concentrating in particular on low cortisol levels and a hypothalamic deficiency. In order to investigate the dynamic response of the adrenal glands, we measured dehydroepiandrosterone (DHEA) in serum after adreno-corticotropic hormone (ACTH) stimulation during 60 minutes in 22 CFS-patients and 14 healthy controls. We found normal basal DHEA levels, but a blunted serum DHEA response curve to i.v. ACTH injection. This observation adds to the large amount of evidence of endocrinological abnormalities in CFS. Relative glucocorticoid deficiency might contribute to the overall clinical picture in CFS, and could explain some of the immunological disturbances observed in this syndrome. |
| Databáze: | OpenAIRE |
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