Nimesulide aggravates kainic acid-induced seizures in the rat
| Autor: | Tina Kunz, Ernst H. Oliw |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Kainic acid Time Factors Health Toxicology and Mutagenesis Analgesic Hippocampus Kainate receptor Pharmacology Toxicology Rats Sprague-Dawley chemistry.chemical_compound Seizures Convulsion medicine Excitatory Amino Acid Agonists Animals Cyclooxygenase Inhibitors Drug Interactions In Situ Hybridization Cerebral Cortex Sulfonamides Kainic Acid biology Behavior Animal business.industry Reverse Transcriptase Polymerase Chain Reaction Blotting Northern Rats Drug Combinations chemistry Enzyme inhibitor Anesthesia Toxicity biology.protein medicine.symptom business Injections Intraperitoneal Nimesulide medicine.drug |
| Zdroj: | Pharmacologytoxicology. 88(5) |
| ISSN: | 0901-9928 |
| Popis: | Treatment of rats with kainic acid (10 mg/kg, intraperitoneally) triggers limbic seizures. Cyclooxygenase-2 mRNA is expressed in the hippocampus and cortex after 8 hr and marked cell loss occurs after 72 hr in the CA1-CA3 areas of the hippocampus. We examined the effect of the cyclooxygenase-2 inhibitor, nimesulide (N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide), on kainate-induced seizures and delayed neurotoxicity. Nimesulide (10 mg/kg, intraperitoneally) was well tolerated given alone or 6-8 hr after kainate. However, pretreatment with nimesulide augmented seizures and increased the mortality rate from approximately 10% to 69%. We examined the effect of nimesulide on delayed cell loss after 72 hr in the surviving animals with histological staining. Cell loss did not seem to be reduced in animals treated with nimesulide 6-8 hr after kainate, but in the surviving animals pretreated with nimesulide less cell loss occurred. We conclude that nimesulide should be used with caution as an antiinflammatory drug in patients with convulsive disorders. |
| Databáze: | OpenAIRE |
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